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化学进展 2014, Vol. 26 Issue (01): 167-177 DOI: 10.7536/PC130616 前一篇   后一篇

• 综述与评论 •

微流控纸芯片的加工技术及其应用

蒋艳, 马翠翠, 胡贤巧, 何巧红*   

  1. 浙江大学化学系 微分析系统研究所 杭州 310058
  • 收稿日期:2013-06-01 修回日期:2013-10-01 出版日期:2014-01-15 发布日期:2013-11-08
  • 通讯作者: 何巧红，e-mail：heqh@zju.edu.cn E-mail:heqh@zju.edu.cn
  • 基金资助:

    国家自然科学基金项目（No. 20890020）和国家科学技术支撑项目（No.2012BAI13B06）资助

下载PDF ( 4064 ) 引用
导出 被引次数 ( 18 | 8 )

Fabrication Techniques of Microfluidic Paper-Based Chips and Their Applications

Jiang Yan, Ma Cuicui, Hu Xianqiao, He Qiaohong*   

  1. Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
  • Received:2013-06-01 Revised:2013-10-01 Online:2014-01-15 Published:2013-11-08
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. 20890020) and the National Key Technology R&D Program of China (No. 2012BAI13B06)

微流控纸芯片是一种新兴的微流控分析技术平台，具有成本低、加工简易、使用和携带方便等优点，在临床诊断、食品质量控制和环境监测等应用领域具有很大的应用前景，近年来，引起广大科学工作者极大的兴趣。本文着重介绍目前文献相继报道的各种纸芯片加工技术，包括紫外光刻、蜡印、等离子体处理、喷墨打印、喷墨溶剂刻蚀、绘图、柔印和激光光刻等技术。此外，还介绍了微流控纸芯片分析中的检测方法及其应用。

关键词： 微流控纸芯片, 微加工, 检测技术, 应用

Microfluidic paper-based chip analysis is a burgeoning microfluidic technique. It possesses great potentials for application in clinical diagnosis, food quality control as well as environmental monitoring due to its attractive features such as low-cost, easy-to-fabricate, easy-to-use and portable.Its importance and utility are widely acknowledged and extensive research has been conducted in the past several years. This paper mainly aims to review the developed techniques for fabrication of microfluidic paper-based chips, including UV photolithography, wax printing, plasma treatment, ink printing, ink jet etching, plotting, screen printing, flexography printing and laser treatment, and so on. The detection methods for the microfluidic paper-based chip analysis and applications of microfluidic paper-based chips are also reviewed.

Contents
1 Introduction
2 Paper choices
3 Fabrication techniques of microfluidic paper-based chips
3.1 UV photolithography technique
3.2 Wax printing technique
3.3 Plasma treatment technique
3.4 Ink printing technique
3.5 Ink jet etching technique
3.6 Plotting technique
3.7 Screen printing and flexography printing technique
3.8 Wax dipping technique
3.9 Laser treatment technique
3.10 Other techniques
4 Detection methods in microfluidic paper-based analytical devices
4.1 Colorimetric detection
4.2 Electrochemical detection
4.3 Chemiluminescence and electrochemilumine-scence detection
5 Applications of microfluidic paper-based analytical devices
5.1 Clinical diagnosis
5.2 Food quality control
5.3 Environmental monitoring
6 Conclusion and perspective

Key words: microfluidic paper-based chips, fabrication, detection methods, applications

中图分类号: 

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