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化学进展 2013, Vol. 25 Issue (04): 457-468 DOI: 10.7536/PC130107 前一篇   后一篇

• 新领域 •

生物介质内形成的金属基生物微粒: 冲击和挑战

王夔*, 杨晓改*   

  1. 北京大学药学院化学生物学系 北京 100191
  • 收稿日期:2013-01-01 修回日期:2013-01-01 出版日期:2013-04-24 发布日期:2013-04-09
  • 通讯作者: 王夔, 杨晓改 E-mail:wangkuipku@gmail.com; yxg@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金项目(No. 21277006)资助

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Metal-Based Particles in Biological Media: Impact and Challenge

Wang Kui*, Yang Xiaogai*   

  1. Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2013-01-01 Revised:2013-01-01 Online:2013-04-24 Published:2013-04-09

在体液、组织、生物界面等生物介质中广泛存在着自发形成的金属基生物微粒, 其中包括在体内原位生成的和异位转化的内源性微粒,也包括外源性微粒在体内被修饰转化所产生的次生微粒。这些在体内形成的微粒的粒径在纳米至微米级之间,它们大都参与生理、病理和毒理过程。但是目前缺乏对它们的生物效应与其形成、结构、性质相关性的研究。本文列举了有关金属基生物微粒的诸多现象和对它们的初步认识, 提出了这方面有待解决的问题, 这方面的研究结果将对环境、健康、疾病控制等领域的研究提供新思路。

关键词： 金属基生物微粒, 生物介质, 生物效应

Spontaneously formed metal-based bioparticles, such as those formed in situ and intrinsic particles transformed ex situ, as well as in vivo modified and transformed extrinsic particles, are often present in the biogical media including body fluids, tissues and biointerfaces. The size of these particles are between nano- and micro- meters. Most of them are involved in the physiological, pathological and toxicological processes. Up to now, however, there is a lack of research on the relationship between the biological effects and the formation, structure and properties of these particles. The present article lists some facts and preliminary understanding about these metal-based bioparticles. Some research areas to be investigated are also proposed. The findings in these areas may provide the insight into the studies on the environment, health, disease control and so on.

Contents
1 Introduction
2 Calcium-based bioparticles under physiological conditions
2.1 Calcium phosphate nanoparticles in bone formation and remodeling
2.2 Calcium phosphate nanoparticles in tooth formation
2.3 Calcium-based nanoparticles under physiological conditions
3 Metal-based bioparticles formed in the pathological process
3.1 Nephronic systemic fibrosis and Gd-containing particles
3.2 Renal failure and deposition of metal-based bioparticles
3.3 Vascular calcification and calcific uremic arteriolopathy
3.4 Calcium-based bioparticles in the stone formation of urinary tract
3.5 Basic calcium phosphate in the synovial fluid
3.6 From nanobacteria to calcifying nanoparticle
4 In vivo modificaton of extrinsic nanoparticles and their biological effects
4.1 In vivo modificaton of extrinsic nanoparticles
4.2 Generality and specificity of nanoparticles-induced toxicity
4.3 The dual biological effects of cerium oxide nanoparticles
5 In vitro formation of metal-based bioparticles
5.1 Formation of metal-based bioparticles in the simulated biological fluid
5.2 Cell-involved formation, transport and transformation of bioparticles
5.3 Influence of metal-based bioparticles on gene transfection efficiency
5.4 Alum as a vaccine adjuvant
6 Summary and perspective

Key words: metal-based particles, biological media, biological effects

中图分类号: 

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