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化学进展 DOI: 10.7536/PC121246 前一篇   后一篇

• 综述与评论 •

糖基胍的研究进展

曹玲华*1,2, 贺耀武1,3, 李根1, 阿吉艾克拜尔·艾萨*1   

  1. 1. 中国科学院干旱区植物资源化学重点实验室 新疆特有药用资源利用省部共建国家重点 实验室培育基地 乌鲁木齐 830011;
    2. 新疆大学化学化工学院 乌鲁木齐 830046;
    3. 中国科学院大学 北京 100049
  • 收稿日期:2012-12-01 修回日期:2013-03-01 出版日期:2013-08-25 发布日期:2013-06-13
  • 通讯作者: 曹玲华,阿吉艾克拜尔·艾萨 E-mail:clhxj@xju.edu.cn;haji@ms.xjb.ac.cn
  • 基金资助:

    国家自然科学基金项目(No.20462006);国家自然科学基金杰出青年科学基金项目(No.30925045)和中国科学院创新团队国际合作伙伴计划项目联合资助

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Progress in Studies of Glycosylgunidines

Cao Linghua*1,2, He Yaowu1,3, Li Gen1, Haji Akber Aisa*1   

  1. 1. Key Laboratory of Chemistry of Plant Resources in Arid Regions, Chinese Academy of Sciences, State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Urumqi 830011, China;
    2. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China;
    3. University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2012-12-01 Revised:2013-03-01 Online:2013-08-25 Published:2013-06-13

许多含有糖基和胍基官能团的天然的及合成的化合物,都具有很强的生物活性,近年来引起研究者的极大兴趣。随着具有高活性的含有糖基和胍基天然产物不断被发现,糖基胍类化合物的合成方法也在不断地改进,包括嗜硫剂以及新型胍基化试剂的使用,使糖基胍类化合物的合成变得更加高效。本文对天然的及合成的糖基胍基化合物的结构及合成方法及其应用进行了较全面的阐述,并对该领域的发展方向提出了我们的看法。

关键词： 糖基胍, 结构, 合成, 应用

A lot of natural guanidine products and synthetic guanidyl compounds were presented potent biological activities. The synthesis of glycosyl guanidines has been attracted continued interests in recent years. With the discovery of natural products containing glycosyl and guandine, synthetic method of glycosyl guanidines has been improved. Thiophilic reagents and guanidinylation reagents have been used to synthesize glycosyl guanidines. In this paper, the structures, the synthetic methods and applications of glycosyl guanidine derivatives are reviewed. The prospects and research direction based on the analysis of this field are given. Contents
1 Introduction
2 Natural products of guanidinoglycoside
3 Synthetic guanidinoglycosides
3.1 Guanidinoglycosides
3.2 Non-anomeric glycosyl guanidines
3.3 Bisglycosyl guanidines
3.4 Guanylation biotinylated aminoglycosides
4 Conclusion and outlook

Key words: glycosylguanidine, structure, synthesis, application

中图分类号: 

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摘要

糖基胍的研究进展