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化学进展 DOI: 10.7536/PC121208 前一篇   后一篇

• 综述与评论 •

纳米颗粒与蛋白质分子的相互作用

许志珍1,2, 晏晓敏3, 张杰2,4, 王煜倩2, 唐仕川*2, 钟儒刚*1   

  1. 1. 北京工业大学生命科学与生物工程学院 北京 100124;
    2. 职业安全健康北京市 重点实验室 北京 100054;
    3. 华南师范大学化学与环境学院 广州 510006;
    4. 北京理工大学爆炸与科学技术国家重点实验室 北京 100081
  • 收稿日期:2012-12-01 修回日期:2013-04-01 出版日期:2013-08-25 发布日期:2013-06-13
  • 通讯作者: 唐仕川,钟儒刚 E-mail:tsc3496@sina.com;lifesci@bjut.edu.cn
  • 基金资助:

    北京市科学技术研究院2012科技创新工程项目(No.PXM2012_178304_000007);北京市财政项目(No.PXM2012_178304_000011_00015203_FCG);国家自然科学基金项目(No.81172614, 21007081)和北京市博士后工作经费资助

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Molecular Interaction of Nanoparticles with Proteins

Xu Zhizhen1,2, Yan Xiaomin3, Zhang Jie2,4, Wang Yuqian2, Tang Shichuan*2, Zhong Rugang*1   

  1. 1. College of Life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China;
    2. Beijing Key Laboratory of Occupational Safety and Health, Beijing 100054, China;
    3. School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China;
    4. State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, China
  • Received:2012-12-01 Revised:2013-04-01 Online:2013-08-25 Published:2013-06-13

纳米技术的快速发展和广泛应用前景,引起了人们对纳米生物效应和安全性问题的普遍关注。为保证纳米技术的健康持续发展,纳米颗粒与生物体的相互作用以及产生的生物学效应不容忽视。为充分了解纳米颗粒物产生的生物学效应,阐明纳米颗粒如何进入生物体以及与生物体相互作用的分子过程至关重要。在总结国内外相关研究的基础上,本文介绍了纳米颗粒进入机体的主要途径,并系统综述了纳米颗粒与蛋白质分子的相互作用及其表征方法,以及纳米颗粒与蛋白质相互作用对蛋白质结构功能和纳米颗粒生物效应的影响。

关键词： 纳米颗粒, 蛋白质, 相互作用, 蛋白质结构, 生物效应

The rapid development of nanotechnology offers wide prospects for the application of nanomaterials in different areas of industry, technology and medicine. Meanwhile, the biological effect and safety of nanoparticles have attracted worldwide attention. To ensure the healthy and sustainable development of nanotechnology, the interaction of nanoparticles with organisms and the biological effect produced by nanoparticles can not be neglected.To understand the biological effects of nanoparticles, investigating how the nanoparticles entrance into organisms and the complicated molecular aspects of nano-bio interactions is crucial. The main routes of nanoparticles entering the organisms are introduced. The interaction of nanoparticles with protein, the influencing factors and characterization of the interaction are reviewed in detail. The effects of nano-protein interaction on the structure and function of protein and the biological impact of nanoparticles are summarized. Contents
1 Introduction
2 The main routes of nanoparticles entrance into the body
2.1 The respiratory system
2.2 The skin
2.3 The gastrointestinal system
3 The interaction of nanoparticles with proteins
4 The characterization of the interaction of nanoparticles with proteins
5 The effect of the interaction of nanoparticles with proteins
5.1 The effect on the structure and function of proteins
5.2 The effect on the characteristics and biological effect of nanoparticles
6 Outlook

Key words: nanoparticles, protein, interaction, protein structure, biological effect

中图分类号: 

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[1] 赵宇亮(Zhao Y L), 柴之芳(Chai Z F). 学科发展(Disciplinary Development), 2005, 20: 194-199
[2] Zhu Q, Talton J, Zhang G, Cunningham T, Wang Z, Waters R C, Kirk J, Eppler B, Klinman D M, Sui Y, Gagnon S, Belyakov I M, Mumper R J, Berzofsky J A. Nat. Med., 2012, 18: 1291-1296
[3] Saraceno R, Chiricozzi A, Botti E, Gramiccia T, Pietroleonardo L, Chimenti S, Souto E B. Patenting Nanomedicines. Springer Berlin Heidelberg, 2012. 383-399
[4] The Project on Emerging Nanotechnologies. [2012-12-01]. http: //www. nanotechproject. org/inventories/consumer/analysis_ draft/
[5] 刘元方(Liu Y F), 陈欣欣(Chen X X), 王海芳(Wang H F). 自然杂志(Chinese Journal of Nature), 2011, 33: 192-197
[6] 晏晓敏(Yan X M), 石宝友(Shi B Y), 王东升(Wang D S), 汤鸿霄(Tang H X). 化学进展(Progress in Chemistry), 2008, 20: 422-428
[7] Oberdörster G, Oberdörster E, Oberdörster J. Environ. Health Persp., 2005, 113: 823-839
[8] 李炜(Li W), 赵峰(Zhao F), 陈春英(Chen C Y), 赵宇亮(Zhao Y L). 化学进展(Progress in Chemistry), 2009, 21: 430-435
[9] Zhao F, Zhao Y, Liu Y, Chang X, Chen C, Zhao Y. Small, 2011, 7: 1322-1337
[10] Sharifi S, Behzadi S, Laurent S, Laird F M, Stroeve P, Mahmoudi M. Chem. Soc. Rev., 2012, 41: 2323-2343
[11] Song Y, Li X, Du X. Eur. Respir. J., 2009, 34: 559-567
[12] Khan M I, Mohammad A, Patil G, Naqvi S A H, Chauhan L K S, Ahmad I. Biomaterials, 2012, 33: 1477-1488
[13] Crosera M, Bovenzi M, Maina G, Adami G, Zanette C, Florio C, Filon L F. Int. Arch. Occ. Env. Hea., 2009, 82: 1043-1055
[14] Shemetov A A, Nabiev I, Sukhanova A. ACS Nano, 2012, 6: 4585-4602
[15] Ge C, Du J, Zhao L, Wang L, Liu Y, Li D, Yang Y, Zhou R, Zhao Y, Chai Z, Chen C. Proc. Nat. Acad. Sci. U. S. A., 2011, 108: 16968-16973
[16] Asuri P, Karajanagi S S, Yang H, Yim T J, Kane R S, Dordick J S. Langmuir, 2006, 22: 5833-5836
[17] Klein J. Proc. Nat. Acad. Sci. U. S. A., 2007, 104: 2029-2030
[18] Chun A L. Nat. Nanotechnol., 2012. doi: 10.1038 /nnano. 2012. 159
[19] Lynch I, Dawson K A. Nano Today, 2008, 3: 40-47
[20] Linse S, Cabaleiro-Lago C, Xue W F, Lynch I, Lindman S, Thulin E, Radford S E, Dawson K A. Proc. Nat. Acad. Sci. U. S. A., 2007, 104: 8691-8696
[21] Walkey C D, Chan W C W. Chem. Soc. Rev., 2012, 41: 2780-2799
[22] Gebauer J S, Malissek M, Simon S, Knauer S K, Maskos M, Stauber R H, Peukert W, Treuel L. Langmuir, 2012, 28: 9673-9679
[23] 庄志雄(Zhuang Z X), 刘建军(Liu J J), 袁建辉(Yuan J H). 纳米毒理学(Nanotoxicology). 北京: 科学出版社(Beijing: Science Press), 2009. 172
[24] Sund J, Alenius H, Vippola M, Savolainen K, Puustinen A. ACS Nano, 2011, 5: 4300-4309
[25] Renwick L C, Brown D, Clouter A, Donaldson K. Occup. Environ. Med., 2004, 61: 442-447
[26] Möller W, Hofer T, Ziesenis A, Karg E, Heyder J. Toxicol. Appl. Pharm., 2002, 182: 197-207
[27] Terzano C, Di Stefano F, Conti V, Graziani E, Petroianni A. Eur. Rev. Med. Pharmacol. Sci., 2010, 14: 809-820
[28] Yokoyama T, Tam J, Kuroda S, Scott A W, Aaron J, Larson T, Shanker M, Correa A M, Kondo S, Roth J A, Sokolov K, Ramesh R. PLoS One, 2011, 6: e25507
[29] 周国强(Zhou G Q), 陈春英(Chen C Y), 李玉锋(Li Y F), 李炜(Li W), 高愈希(Gao Y X), 赵宇亮(Zhao Y L). 生物化学与生物物理进展(Progress in Biochemistry and Biophysics), 2008, 35: 998-1006
[30] Ryman-Rasmussen J P, Riviere J E, Monteiro-Riviere N A. J. Invest. Dermatol., 2006, 127: 143-153
[31] Sarkar S, Sharma C, Yog R, Periakaruppan A, Jejelowo O, Thomas R. J. Nanosci. Nanotechnol., 2009, 7: 584-592
[32] Cohen D, Soroka Y, Ma'or Z, Oron M, Portugal-Cohen M, Brégégère FM, Berhanu D, Valsami-Jones E, Hai N, Milner Y. Toxicol. in Vitro, 2012, 27: 292-298
[33] Ryman-Rasmussen J P, Riviere J E, Monteiro-Riviere N A. Toxicol. Sci., 2006, 91: 159-165
[34] Rancan F, Gao Q, Graf C, Troppens S, Hadam S, Hackbarth S, Kembuan C, Blume-Peytavi U, Rühl E, Lademann J, Vogt A. ACS Nano, 2012, 6: 6829-6842
[35] Larese F F, D'Agostin F, Crosera M, Adami G, Renzi N, Bovenzi M, Maina G. Toxicology, 2009, 255: 33-37
[36] Prow T W, Monteiro-Riviere N A, Erdmann D, Riviere J E, Roberts M S, Inman A O, Grice J E, Chen X, Zhao X, Sanchez W H, Gierden A, Kendall M A F, Zvyagin A V. Nanotoxicology, 2012, 6: 173-185
[37] Nohynek G, Dufour E. Arch. Toxicol., 2012, 86: 1063-1075
[38] Chen X, Schluesener H J. Toxicol. Lett., 2008, 176: 1-12
[39] Slütter B, Plapied L, Fievez V, Alonso S M, des Rieux A, Schneider Y J, van Riet E, Jiskoot W, Prat V. J. Control Release, 2009, 138: 113-121
[40] Jain A K, Goyal A K, Mishra N, Vaidya B, Mangal S, Vyas S P. Int. J. Pharm., 2010, 387: 253-262
[41] Winter M, Beer H D, Hornung V, Krämer U, Schins R P F, Förster I. Nanotoxicology, 2011, 5: 326-340
[42] He C, Yin L, Tang C, Yin C. Biomaterials, 2012, 33: 8569-8578
[43] Van der Zande M, Vandebriel R J, van Doren E, Kramer E, Herrera R Z, Serrano-Rojero C S, Gremmer E R, Mast J, Peters R J B, Hollman P C H, Hendriksen P J M, Marvin H J P, Peijnenburg A A C M, Bouwmeester H. ACS Nano, 2012, 6: 7427-7442
[44] Muthusamy B, Hanumanthu G, Suresh S, Rekha B, Srinivas D, Karthick L, Vrushabendra B M, Sharma S, Mishra G, Chatterjee P, Mangala K S, Shivashankar H N, Chandrika K N, Deshpande N, Suresh M, Kannabiran N, Niranjan V, Nalli A, Prasad T S K, Arun K S, Reddy R, Chandran S, Jadhav T, Julie D, Mahesh M, John S L, Palvankar K, Sudhir D, Bala P, Rashmi N S, Vishnupriya G, Dhar K, Reshma S, Chaerkady R, Gandhi T K B, Harsha H C, Mohan S S, Deshpande K S, Sarker M, Pandey A. Proteomics, 2005, 5: 3531-3536
[45] Cedervall T, Lynch I, Foy M, Berggård T, Donnelly S C, Cagney G, Linse S, Dawson K A. Angew. Chem. Int. Edit., 2007, 46: 5754-5756
[46] Lunov O, Syrovets T, Loos C, Beil J, Delacher M, Tron K, Nienhaus G U, Musyanovych A, Mailänder V, Landfester K, Simmet T. ACS Nano, 2011, 5: 1657-1669
[47] Cole A J, David A E, Wang J, Galbán C J, Hill H L, Yang V C. Biomaterials, 2011, 32: 2183-2193
[48] Gagner J E, Shrivastava S, Qian X, Dordick J S, Siegel R W. J. Phys. Chem. Lett., 2012, 3: 3149-3158
[49] Anand G, Sharma S, Dutta A K, Kumar S K, Belfort G. Langmuir, 2010, 26: 10803-10811
[50] Deng Z J, Liang M, Toth I, Monteiro M, Minchin R F. Nanotoxicology, 2012, 7: 314-322
[51] Gagner J E, Lopez M D, Dordick J S, Siegel R W. Biomaterials, 2011, 32: 7241-7252
[52] De M, Miranda O R, Rana S, Rotello V M. Chem. Commun., 2009, 2157-2159
[53] Aggarwal P, Hall J B, McLeland C B, Dobrovolskaia M A, McNeil S E. Adv. Drug Deliv. Rev., 2009, 61: 428-437
[54] Cedervall T, Lynch I, Lindman S, Berggård T, Thulin E, Nilsson H, Dawson K A, Linse S. Proc. Nat. Acad. Sci. U. S. A., 2007, 104: 2050-2055
[55] Lindman S, Lynch I, Thulin E, Nilsson H, Dawson K A, Linse S. Nano Letters, 2007, 7: 914-920
[56] Gebauer J S, Malissek M, Simon S, Knauer S K, Maskos M, Stauber R H, Peukert W, Treuel L. Langmuir, 2012, 28: 9673-9679
[57] Chakraborti S, Joshi P, Chakravarty D, Shanker V, Ansari Z A, Singh S P, Chakrabarti P. Langmuir, 2012, 28: 11142-11152
[58] Boyer C, Huang X, Whittaker M R, Bulmus V, Davis T P. Soft Matter, 2011, 7: 1599-1614
[59] Peiris R H, Ignagni N, Budman H, Moresoli C, Legge R L. Talanta, 2012, 99: 457-463
[60] Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson K A. Adv. Colloid Interface Sci., 2007, 134/135: 167-174
[61] Gagner J E, Qian X, Lopez M M, Dordick J S, Siegel R W. Biomaterials, 2012, 33: 8503-8516
[62] Norde W. Colloids and Surfaces. B: Biointerfaces, 2008, 61: 1-9
[63] Asuri P, Bale S S, Karajanagi S S, Kane R S. Curr. Opin. Biotech., 2006, 17: 562-568
[64] Roach P, Farrar D, Perry C C. J. Am. Chem. Soc., 2006, 128: 3939-3945
[65] Cabaleiro-Lago C, Lynch I, Dawson K A, Linse S. Langmuir, 2010, 26: 3453-3461
[66] Colvin V L, Kulinowski K M. Proc. Nat. Acad. Sci. U. S. A., 2007, 104: 8679-8680
[67] Zhang D, Neumann O, Wang H, Yuwono V M, Barhoumi A, Perham M, Hartgerink J D, Wittung-Stafshede P, Halas N J. Nano Letters, 2009, 9: 666-671
[68] Vertegel A A, Siegel R W, Dordick J S. Langmuir, 2004, 20: 6800-6807
[69] Deng Z J, Liang M, Monteiro M, Toth I, Minchin R F. Nat. Nano, 2011, 6: 39-44
[70] Calzolai L, Franchini F, Gilliland D, Rossi F. Nano Letters, 2010, 10: 3101-3105
[71] Bharti B, Meissner J, Findenegg G H. Langmuir, 2011, 27: 9823-9833
[72] Lacerda S H D P, Park J J, Meuse C, Pristinski D, Becker M L, Karim A, Douglas J F. ACS Nano, 2009, 4: 365-379
[73] Lesniak A, Fenaroli F, Monopoli M P, berg C, Dawson K A, Salvati A. ACS Nano, 2012, 6: 5845-5857
[74] Zhu Y, Li W, Li Q, Li Y, Li Y, Zhang X, Huang Q. Carbon, 2009, 47: 1351-1358
[75] Walkey C D, Olsen J B, Guo H, Emili A, Chan W C W. J. Am. Chem. Soc., 2011, 134: 2139-2147
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