English
往期目录
新闻公告
More
化学进展 2013, Vol. 25 Issue (04): 469-478 DOI: 10.7536/PC121136 前一篇   后一篇

• 新领域 •

转化医学研究中的生物无机化学问题探讨

张金超*1, 胡毅*2, 余四旺3, 高愈希2, 张海松4   

  1. 1. 河北大学化学与环境科学学院 河北省化学生物学重点实验室 保定 07100;
    2. 中国科学院核分析技术重点实验室 中国科学院纳米生物效应与安全性重点实验室 中国科学院高能物理研究所 北京 100049;
    3. 北京大学药学院化学生物学系 天然药物与 仿生药物国家重点实验室 北京 100191;
    4. 河北大学附属医院 保定071000
  • 收稿日期:2012-11-01 修回日期:2012-12-01 出版日期:2013-04-24 发布日期:2013-04-09
  • 通讯作者: 张金超, 胡毅 E-mail:jczhang6970@yahoo.com.cn;huyi@ihep.ac.cn
  • 基金资助:

    国家自然科学基金项目(No. 21271059);高等学校博士点基金项目(No. 20111301110004);中国科学院高能物理研究所科技创新项目 (Y2515560U1)和国家重点基础研究发展计划(973)项目 (No.2011CB933101)资助

下载PDF ( 1416 ) 引用
导出 被引次数 ( 1 )

The Study of Biological Inorganic Chemistry Problemsin Translational Medicine

Zhang Jinchao*1, Hu Yi*2, Yu Siwang3, Gao Yuxi2, Zhang Haisong4   

  1. 1. Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 07100;
    2. CAS Key Laboratory of Nuclear Analytical Techniques, Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;
    3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, Beijing 100191, China;
    4. Affiliated Hospital of Hebei University, Baoding 071000, China
  • Received:2012-11-01 Revised:2012-12-01 Online:2013-04-24 Published:2013-04-09

转化医学是进入21世纪以来国际生物医学及健康领域出现的新概念。它是基础研究到临床应用的双向过程,是临床实践与基础研究之间的循环式的研究体系, 它不是一门新的学科,只是强调一种理念,是特定时代背景的产物。目前, 转化医学研究主要涉及以下领域:肿瘤、心脑血管疾病、代谢疾病、精神疾病、运动系统疾病、遗传病、器官移植、组织工程、疾病诊断、药物研发、个体化治疗、干细胞研究、动物模型研究以及免疫学等。本文综述了在疾病诊断、组织工程领域、个体化治疗、新药研发以及发病机制中涉及到的生物无机化学问题。最后, 展望了该新领域今后的发展方向和亟待研究的重要问题。

关键词： 转化医学, 生物无机化学, 疾病诊断, 个体化治疗, 组织工程, 药物研发, 金属内稳态, 活性氧(氮)的内稳态

Translational medicine is an emerging concept in the fields of biomedical research and healthcare since twenty-first century. It is a two-way process from the basic research to clinical application with direct feedbacks in between. It is not a new subject, but emphasizes a concept. It stems from an unmet need in clinical medicine. At present, translational medical research is mainly involved in the following areas: cancer, cardiovascular diseases, metabolic disorders, psychiatric disorders, diseases of the locomotor system, genetic diseases, organ transplantation, tissue engineering, disease diagnosis, drug research and development, personalized therapy, stem cell research, animal model studies and immunology etc. This article reviews the bioinorganic chemistry problems involved in the disease diagnosis, tissue engineering, individual therapy, drug research and development and disease mechanisms. Finally, the development of this new area and important issues to be studied are outlooked.Contents
1 The bioinorganic chemistry problems in disease diagnosis
1.1 New diagnosis methods
1.2 Imaging technology
2 The bioinorganic chemistry problems in tissue engineering
3 The bioinorganic chemistry problems in individual therapy
4 The bioinorganic chemistry problems in drug research and development
4.1 From single-target drug design to systematic intervention
4.2 Emerging nanomedicine
5 The bioinorganic chemistry problems in molecular mechanisms of diseases
5.1 The relationship between metal homeostasis and neurodegenerative diseases
5.2 The relationship between oxygen (nitrogen) homeostasis and neurodegenerative diseases
6 Outlook

Key words: translational medicine, biological inorganic chemistry, disease diagnosis, individual therapy, tissue engineering, drug research and development, metal homeostasis, oxygen (nitrogen) homeostasis

中图分类号: 

()

[1] Choi D W. Science, 1992, 258 (5080): 241-243
[2] Geller R B, Karl J E. Blood, 1994, 84(11): 3980-3981
[3] Geraghty J A. Lancet, 1996, 348(9025): 422-424
[4] Zerhouni E. Science, 2003, 302(5642): 63-72
[5] 康娟(Kang J), 张新祥(Zhang X X). 化学进展(Progress in Chemistry), 2006, 18(11): 1523-1529
[6] Ye Z Q, Tan M Q, Wang G L, Yuan J L. Anal. Chem., 2004, 76: 513-518
[7] Ye Z Q, Tan M Q, Wang G L, Yuan J L. Chem. Mater., 2004, 16: 2494-2498
[8] Ye Z Q, Tan M Q, Wang G L, Yuan J L. J. Mater. Chem., 2004, 14: 851-856
[9] Matsuya T, Tashiro S, Hoshino N, Shibata N, Nagasaki Y, Kataoka K. Anal. Chem., 2003, 75: 6124-6132
[10] Elghanian R, Storhoff J J, Mucic R C, Letsinger R L, Mirkin C A. Science, 1997, 277(5329): 1078-1081
[11] Fang S, Lee H, Wark A W, Corn R M. J. Am. Chem. Soc., 2006, 128: 14044-14046
[12] 何文蕾(He W L), 杨文杰(Yang W J), 李媛媛( Li Y Y), 徐顺清( Xu S Q ). 生物化学与生物物理进展( Progress in Biochemistry and Biophysics), 2008, 35: 1332-1338
[13] Gao Z, Yang Z. Anal. Chem., 2006, 78: 1470-1477
[14] Strijkers G J, Mulder M, Willem J, van Tilborg F, Geralda A, Nicolay K. Curr. Med. Chem., 2007, 7(3): 291-305
[15] Takeshita K, Nagashima I, Frui S. J. Comput. Assist. Tomo., 2002, 26(3): 451-455
[16] Bruchez M, Jr Moronne M, Gin P, Weiss S, Alivisatos A P. Science, 1998, 281(5385): 2013-2016
[17] Chan W C, Nie S. Science, 1998, 281(5385): 2016-2018
[18] Kim S, Lim Y T, Soltesz E G, De Grand A M, Lee J, Nakayama A, Parker J A, Mihaljevic T, Laurence R G, Dor D M, Cohn L H, Bawendi M G, Frangioni J V. Nat. Biotechnol., 2004, 22(1): 93-97
[19] Walther C, Meyer K, Rennert R, Neundorf I. Bioconjugate Chem., 2008, 19 (12): 2346-2356
[20] Xiong L Q, Chen Z G, Tian Q W, Cao T Y, Xu C J, Huang C H. Anal. Chem., 2009, 81(21): 8687-8694
[21] Langer R, Vacanti J P. Science, 1993, 260(5110): 920-926
[22] Challa K. Tissue, Cell and Organ Engineering. Weinheim: WILEY-VCH Verlag GmbH & Co., 2006. 1-519
[23] 张金超(zhang J C), 刘丹丹(Liu D D), 周国强(Zhou G Q), 申世刚(Shen S G). 化学进展(Progress in Chemistry), 2010, 22(11): 2232-2237
[24] 范群英(Fan Q Y), 詹红兵(Zhan H B). 化学进展(Progress in Chemistry), 2012, 24(1): 54-60
[25] 王夔(Wang K). 中国处方药(China Prescription Drug), 2003, (10): 48-51
[26] Wang K, Yu S, Zhang T. Arsenic in Traditional Chinese Medicine. Biological Chemistry of Arsenic, Antimony and Bismuth, (Ed. Sun H Z). John Wiley & Sons, Inc., 2011
[27] Zhu J, Chen Z, Lallemand-Breitenbach V, de The H. Nat. Rev. Cancer, 2002, 2(9): 705-713
[28] 孙洪德(Sun H D), 李元善(Li Y S), 马玲(Ma L). 中国中西医结合杂志(Chinese Journal of Integrative Medicine), 1992, 12(3): 170-174
[29] Zhang X W, Yan X J, Zhou Z R, Yang F F, Wu Z Y, Sun H B, Liang W X, Song A X, Lallemand-Breitenbach V, Jeanne M, Zhang Q Y, Yang H Y, Huang Q H, Zhou G B, Tong J H, Zhang Y, Wu J H, Hu H Y, de Thé H, Chen S J, Chen Z. Science, 2010, 328(5975): 240-243
[30] Koberle B, Tomicic M T, Usanova S, Kaina B. Biochim. Biophys. Acta, 2010, 1806(2): 172-182
[31] Wong E, Giandomenico C M. Chem. Rev., 1999, 99(9): 2451-2466
[32] Simon G R, Ismail-Khan R, Bepler G. Int. J. Biochem. Cell Biol., 2007, 39(7/8): 1318-1328
[33] Olaussen K A, Dunant A, Fouret P, Brambilla E, Andre F, Haddad V, Taranchon E, Filipits M, Pirker R, Popper H H. N. Engl. J. Med., 2006, 355(10): 983-991
[34] Fricker S P. Chem. Soc. Rev., 2006, 35(6): 524-533
[35] Swainston H T, Scott L J. Drugs, 2004, 64(9): 985-996
[36] Peterson V M, Hansbrough J F, Wang X W, Zapata-Sirvent R, Boswick J A. J. Trauma., 1985, 25(11): 1039-1044
[37] Thompson K H, Orvig C. Chem. Soc. Rev., 2006, 35: 499-499
[38] 王夔(Wang K), 杨晓改(Yang X G). 化学进展(Progress in Chemistry), 2009, 21(5): 803-818
[39] 杨晓改(Yang X G), 杨晓达(Yang X D), 王夔(Wang K). 化学进展(Progress in Chemistry), 2007, 19(2/3): 201-204
[40] 罗忠(Luo Z), 蔡开勇(Cai K Y), 张蓓璐(Zhang P L), 段霖(Duan L), 刘艾萍(Liu W P), 龚端(Gong D). 化学进展(Progress in Chemistry), 2011, 23(11): 2326-2338
[41] Feazell R P, Nakayama-Ratchford N, Dai H, Lippard S J. J. Am. Chem. Soc., 2007, 129(27): 8438-8439
[42] Min Y Z, Mao C Q, Chen S M, Ma G L, Wang J, Liu Y Z. Angew. Chem. Int. Ed., 2012, 51: 6742-6747
[43] Zhang J, Wang X, Xu T. Toxicol. Sci., 2008, 101(1): 22-31
[44] Silva G A. Nat. Nanotechnol., 2006, 1: 92-94
[45] Chen C Y, Xing G M, Wang J X, Zhao Y L, Li B, Tang J, Jia G, Wang T C, Sun J, Xing L, Yuan H, Gao Y X, Meng H, Chen Z, Zhao F, Chai Z F, Fang X H. Nano Lett., 2005, 5(10): 2050-2057
[46] Yin J J, Lao F, Meng J, Fu P P, Zhao Y L, Xing G M, Gao X Y, Sun B Y, Wang P C, Chen C Y, Liang X J. Mol. Pharmacol., 2008, 74(4): 1132-1140
[47] Jiao F, Qu Y, Zhou G Q, Liu Y, Li W, Ge C, Li Y, Hu W, Li B, Gao Y X, Chen C Y. J. Nanosci. Nanotechnol., 2010, 10 (12): 8632-8637
[48] Liang X J, Meng H, Wang Y Z, He H Y, Meng J, Lu J, Wang P C, Zhao Y L, Gao Y X, Sun B Y, Chen C Y, Xing G M, Shen D W, Gottesman M M, Wu Y, Yin J J, Jia L. Proc. Natl. Acad. Sci. U. S. A., 2010, 107(16): 7449-7454
[49] Yin J J, Lao F, Fu P P, Wamer W G, Zhao Y L, Wang P C, Qiu Y, Sun B Y, Xing G M, Dong J Q, Liang X J, Chen C Y. Biomaterials, 2009, 30: 611-621
[50] Bourassa M W, Miller L M. Metallomics, 2012, 4: 721-738
[51] McCleskey T M, Buchner V, Field R W, Scott B L. Rev. Environ. Health, 2009, 24: 75-115
[52] Pasricha S R. Pathology, 2012, 44: 139-147
[53] Fairweather-Tait S J, Bao Y, Broadley M R, Collings R, Ford D, Hesketh J E, Hurst R. Antioxid. Redox Signal., 2011, 14: 1337-1383
[54] Banaszak K, Martin-Diaconescu V, Bellucci M, Zambelli B, Rypniewski W, Maroney M J, Ciurli S. Biochem. J., 2012, 441: 1017-1026
[55] Hu Y, Tong Y R. Sci. Signal., 2010, 3: art. no. pe13
[56] Hu Y, Chopra V, Chopra R, Locascio J J, Liao Z, Ding H, Zheng B, Matson W R, Ferrante R J, Rosas H D, Hersch S M, Scherzer C R. Proc. Natl. Acad. Sci. U. S. A., 2011, 108: 17141-17146
[57] Marras C, Goldman S M. Semin. Neurol., 2011, 31: 553-562
[58] Horning M S, Blakemore L J, Trombley P Q. Brain Res., 2000, 852: 56-61
[59] Carlson E S, Tkac I, Magid R, O'Connor M B, Andrews N C, Schallert T, Gunshin H, Georgieff M K, Petryk A. J. Nutr., 2009, 139: 672-679
[60] Sriram K, Lin G X, Jefferson A M, Roberts J R, Andrews R N, Kashon M L, Antonini J M. Toxicology, 2012, 291: 73-82
[61] Johansson A S, Vestling M, Zetterstrom P, Lang L, Leinartaite L, Karlstrom M, Danielsson J, Marklund S L, Oliveberg M. PLoS One, 2012, 7: art. no. e36104
[62] Waggoner D J, Bartnikas T B, Gitlin J D. Neurobiol. Dis., 1999, 6: 221-230
[63] Siggs O M, Cruite J T, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone M B. Proc. Natl. Acad. Sci. U. S. A., 2012, 109: 13733-13738
[64] Wright R O, Baccarelli A. J. Nutr., 2007, 137: 2809-2813
[65] Hu Y, Wang G, Chen G Y J, Fu X, Yao S Q. Electrophoresis, 2003, 24: 1458-1470
[66] Arita A, Shamy M Y, Chervona Y, Clancy H A, Sun H, Hall M N, Qu Q, Gamble M V, Costa M. J. Trace Elem. Med. Biol., 2012, 26: 174-178
[67] Duce J A, Tsatsanis A, Cater M A, James S A, Robb E, Wikhe K, Leong S L, Perez K, Johanssen T, Greenough M A, Cho H H, Galatis D, Moir R D, Masters C L, McLean C, Tanzi R E, Cappai R, Barnham K J, Ciccotosto G D, Rogers J T, Bush A I. Cell, 2010, 142: 857-867
[68] Ebrahimi K H, Hagedoorn P L, Hagen W R. PLoS One, 2012, 7: art. no. e40287
[69] 李玉锋(Li Y F), 陈春英(Chen C Y), 邢丽(Xing L), 刘涛(Liu T), 谢亚宁(Xie Y N), 高愈希(Gao Y X), 李柏(Li B), 瞿丽雅(Qu L Y), 柴之芳(Chai Z F). 核技术(Nuclear Techniques), 2004, 27: 899-903
[70] 胡良(Hu L), 董泽琴(Dong Z Q), 黄笑寒(Huang X H), 李玉锋(Li Y F), 李柏(Li B), 瞿丽雅(Qu L Y), 王国平(Wang G P), 高愈希(Gao Y X), 陈春英(Chen C Y). 分析化学(Chinese Journal of Analytical Chemistry), 2011, 39: 466-470
[71] Davies P, Moualla D, Brown D R. PLoS One, 2011, 6: art. no. e15814
[72] Tai C H, Yang Y C, Pan M K, Huang C S, Kuo C C. J. Clin. Invest., 2011, 121: 3289-3305
[73] Surmeier D J, Guzman J N, Sanchez J, Schumacker P T. Cold Spring Harb. Perspect. Med., 2012, 2: art. no. a009290
[74] Irvine G B, El-Agnaf O M, Shankar G M, Walsh D M. Mol. Med., 2008, 14: 451-464
[75] Uversky V N, Li J, Fink A L. J. Biol. Chem., 2001, 276: 44284-44296
[76] Budimir A. Acta Pharm., 2011, 61: 1-14
[77] Atwood C S, Moir R D, Huang X, Scarpa R C, Bacarra N M, Romano D M, Hartshorn M A, Tanzi R E, Bush A I. J. Biol. Chem., 1998, 273: 12817-12826
[78] Huang X, Atwood C S, Moir R D, Hartshorn M A, Tanzi R E, Bush A I. J. Biol. Inorg. Chem., 2004, 9: 954-960
[79] Crouch P J, Hung L W, Adlard P A, Cortes M, Lal V, Filiz G, Perez K A, Nurjono M, Caragounis A, Du T, Laughton K, Volitakis I, Bush A I, Li Q X, Masters C L, Cappai R, Cherny R A, Donnelly P S, White A R, Barnham K J. Proc. Natl. Acad. Sci. U. S. A., 2009, 106: 381-386
[80] Lucas H R, Lee J C. Metallomics, 2011, 3: 280-283
[81] Wright J A, Wang X, Brown D R. FASEB J., 2009, 23: 2384-2393
[82] Binolfi A, Rodriguez E E, Valensin D, D'Amelio N, Ippoliti E, Obal G, Duran R, Magistrato A, Pritsch O, Zweckstetter M, Valensin G, Carloni P, Quintanar L, Griesinger C, Fernandez C O. Inorg. Chem., 2010, 49: 10668-10679
[83] Castello M A, Soriano S. Ageing Res. Rev., 2012, 12: 282-288.
[84] Selkoe D J. Science, 2012, 337: 1488-1492
[85] Jomova K, Valko M. Toxicology, 2011, 283: 65-87
[86] Koppula S, Kumar H, More S V, Lim H W, Hong S M, Choi D K. Molecules, 2012, 17: 11391-11420
[87] Chervona Y, Costa M. Free Radic. Biol. Med., 2012, 53: 1041-1047
[88] Akhtar M W, Sunico C R, Nakamura T, Lipton S A. Int. J. Cell Biol., 2012, 2012: art. no. 463756
[89] Guglielmotto M, Giliberto L, Tamagno E, Tabaton M. Front. Ag. Neurosci., 2010, 2: art. no. 3
[90] Cole N B, Murphy D D, Lebowitz J, Di Noto L, Levine R L, Nussbaum R L. J. Biol. Chem., 2005, 280: 9678-9690
[91] Wilhelmus M M, Nijland P G, Drukarch B, de Vries H E, van Horssen J. Free Radic. Biol. Med., 2012, 53: 983-992
[92] Cookson M R. Cold Spring Harb. Perspect. Med., 2012, 2: art. no. a009415
[93] Jomova K, Vondrakova D, Lawson M, Valko M. Mol. Cell. Biochem., 2010, 345: 91-104
[94] Finkel T. Sci. Signal., 2012, 5: art. no. pe10
[95] Francis S H, Busch J L, Corbin J D, Sibley D. Pharmacol. Rev., 2010, 62: 525-563
[96] Martinez-Ruiz A, Cadenas S, Lamas S. Free Radic. Biol. Med., 2011, 51: 17-29
[97] Lipton S A, Choi Y B, Pan Z H, Lei S Z, Chen H S, Sucher N J, Loscalzo J, Singel D J, Stamler J S. Nature, 1993, 364: 626-632
[98] Choi Y B, Tenneti L, Le D A, Ortiz J, Bai G, Chen H S, Lipton S A. Nat. Neurosci., 2000, 3: 15-21
[99] Sen N, Hara M R, Ahmad A S, Cascio M B, Kamiya A, Ehmsen J T, Agrawal N, Hester L, Dore S, Snyder S H, Sawa A. Neuron, 2009, 63: 81-91
[100] Bashkatova V, Alam M, Vanin A, Schmidt W J. Exp. Neurol., 2004, 186: 235-241
[101] Uehara T, Nakamura T, Yao D, Shi Z Q, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton S A. Nature, 2006, 441: 513-517
[102] Poderoso J J, Carreras M C, Lisdero C, Riobo N, Schopfer F, Boveris A. Arch. Biochem. Biophys., 1996, 328: 85-92
[103] Zhang Y J, Xu Y F, Liu Y H, Yin J, Li H L, Wang Q, Wang J Z. FASEB J., 2006, 20: 1431-1442
[1] 李红, 史晓丹, 李洁龄. 肽自组装水凝胶的制备及在生物医学中的应用[J]. 化学进展, 2022, 34(3): 568-579.
[2] 牛小连, 刘柯君, 廖子明, 徐慧伦, 陈维毅, 黄棣. 基于骨组织工程的静电纺纳米纤维[J]. 化学进展, 2022, 34(2): 342-355.
[3] 左新钢, 张昊岚, 周同, 高长有. 调控细胞迁移和组织再生的生物材料研究[J]. 化学进展, 2019, 31(11): 1576-1590.
[4] 李雯雯, 段忆翔. 人体呼出气分析的技术进展及其在非侵入式医学诊断方面的临床应用前景[J]. 化学进展, 2015, 27(4): 321-335.
[5] 赵君, 黄仁亮, 齐崴, 王跃飞, 苏荣欣, 何志敏. 苯丙氨酸二肽类分子自组装：分子设计、结构调控与材料应用[J]. 化学进展, 2014, 26(09): 1445-1459.
[6] 孙盟盟, 何勇, 杨万泰, 尹梅贞. 磷酸乙二酯类聚合物的合成及其生物应用[J]. 化学进展, 2013, 25(12): 2093-2102.
[7] 王晓红*, 甘露, Heinz C. Schröder, Werner E.G. Müller*. 生物无机化学范式的转变: 硅质海绵动物中二氧化硅的酶促缩聚反应[J]. 化学进展, 2013, 25(04): 435-445.
[8] 张金超 刘丹丹 周国强 申世刚. 纳米材料在组织工程中的应用*[J]. 化学进展, 2010, 22(11): 2232-2237.
[9] 姚响,庹新林,王晓工. 可降解聚氨酯型组织工程多孔支架材料的制备* [J]. 化学进展, 2009, 21(0708): 1546-1552.
[10] 徐辉碧,杨晓达. 苟日新，日日新，又日新---值王夔教授八十寿诞侧记我国生物无机化学研究[J]. 化学进展, 2008, 20(05): 625-628.
[11] 魏宏亮,王连才,张爱英,朱凯强,冯增国. 可注射水凝胶的制备与应用*[J]. 化学进展, 2004, 16(06): 1008-.
[12] 毛宗万,安燕,计亮年. 关于我国生物无机化学发展战略的一点思考[J]. 化学进展, 2004, 16(04): 660-.
[13] 何成江,王梅,李敏娜,孙立成. 化学模拟唯铁氢化酶研究进展*[J]. 化学进展, 2004, 16(02): 250-.
[14] 崔俊锋,尹玉姬,何淑兰,姚康德. 骨组织工程支架材料研究进展*[J]. 化学进展, 2004, 16(02): 299-.
[15] 黄开勋,刘琼,杨祥良,徐辉碧. 无机小分子与细胞中生物大分子的相互作用*[J]. 化学进展, 2004, 16(02): 308-.