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化学进展 2013, Vol. 25 Issue (04): 446-456 DOI: 10.7536/PC121131 前一篇   后一篇

• 新领域 •

必需金属的生物信息学研究现状与展望

李高鹏, 张焱*   

  1. 中国科学院上海生命科学研究院 营养科学研究所 上海 200031
  • 收稿日期:2012-11-01 修回日期:2013-01-01 出版日期:2013-04-24 发布日期:2013-04-09
  • 通讯作者: 张焱 E-mail:yanzhang01@sibs.ac.cn
  • 基金资助:

    国家自然科学基金项目(No. 31171233)和中国科学院百人计划项目(No. 2012OHTP10)资助

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Progress in Bioinformatics Studies on Essential Metals

Li Gaopeng, Zhang Yan*   

  1. Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2012-11-01 Revised:2013-01-01 Online:2013-04-24 Published:2013-04-09

金属元素在整个生物界被广泛利用。生物体所必需的金属中除了钾、钙、钠和镁以外均属于微量元素。它们虽然在体内含量很少,但在各种生命活动中发挥着重要的作用。一直以来关于必需金属的研究工作主要集中在金属蛋白和相关代谢机制的实验研究上。随着近年来基因组、蛋白质组等组学数据的不断积累,为开展金属、金属组和金属蛋白质组等相关的生物信息学研究工作提供了重要的条件,让我们可以从系统的角度去进一步认识必需金属的利用、代谢及其生物学功能。本文将分别对若干必需金属(包括铜、钼、镍、钴、锌、铁和硒等)相关的生物信息学研究进展进行介绍,并结合当前离子组学相关的技术方法和研究现状。希望本文有助于我们进一步认识必需金属研究领域的重要问题和未来的发展方向。

关键词： 金属, 金属蛋白, 微量元素, 生物信息学, 比较基因组学, 离子组学

Metals are utilized through the three domains of life. Except for potassium, calcium, sodium and magnesium, all essential metals are trace elements. They play important roles in a variety of biological processes, but are needed in very small quantities. Previously, much effort has been focused on experimental studies of metal utilization pathways and metalloproteins. However, with the accumulation of large amount of data from genomics and proteomics studies, it becomes necessary and possible for computational and systematic analyses of the metallomes (or metalloproteomes) to be carried on, which would provide new insights into metal utilization, metabolization and biological functions. In this review, we introduce recent advances in bioinformatics studies on several metals, such as copper, molybdenum, nickel, cobalt, zinc, iron and the metalloid selenium. Furthermore, we also discuss the major techniques and recent advances of high-throughput ionomics studies. We hope that this review may provide a foundation for investigating the fundamental questions and future directions of metal research.

Contents
1 Introduction
2 Copper
3 Molybdenum
4 Nickel and cobalt
5 Zinc
6 Iron
7 Selenium
8 Ionomics
9 Conclusions and outlook

Key words: metal, metalloprotein, trace element, bioinformatics, comparative genomics, ionomics

中图分类号: 

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