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化学进展 2013, Vol. 25 Issue (07): 1131-1141 DOI: 10.7536/PC121122 前一篇   后一篇

• 综述与评论 •

抗癌多金属氧酸盐

王路1,2, 周百斌2*, 刘家仁3   

  1. 1. 哈尔滨工业大学生物化工系 哈尔滨 150090;
    2. 功能材料的设计合成与绿色催化黑龙江省高校重点实验室 哈尔滨师范大学 哈尔滨 150025;
    3. Harvard Medical School (CHB), 300 Longwood Ave, Boston, Ma 02115-5737
  • 收稿日期:2012-11-01 修回日期:2012-12-01 出版日期:2013-07-25 发布日期:2013-04-16
  • 通讯作者: 周百斌 E-mail:zhou_bai_bin@163.com
  • 基金资助:

    国家自然科学基金项目(No. 20971032, 21271056)、黑龙江省自然科学基金项目(No. C201037)、 黑龙江省博士后基金 (LBH-Z10292)和黑龙江省高校科技创新团队建设基金 (2009td04)资助

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Anticancer Polyoxometalates

Wang Lu1,2, Zhou Baibin2*, Liu Jiaren3   

  1. 1. Department of Biochemical Engineering, Harbin Institute of Technology, Harbin 150090, China;
    2. Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Heilongjiang Province, Harbin Normal University, Harbin 150025, China;
    3. Harvard Medical School (CHB), 300 Longwood Ave, Boston, Ma 02115-5737, USA
  • Received:2012-11-01 Revised:2012-12-01 Online:2013-07-25 Published:2013-04-16

多金属氧酸盐具有独特的结构特征及优良的理化性能,已引起国内外科技工作者极大的兴趣与关注,特别是多金属氧酸盐作为抗癌化疗药物的研究,更成为本领域科学研究的前沿之一。本文综述了多金属氧酸盐作为抗癌生物活性药物的国内外研究进展, 其内容主要包括多金属氧酸盐抗癌作用依据,同多、杂多金属氧酸盐不同结构类型的体外抗癌作用、体内抗癌作用及其抗癌作用机制等,提出了多金属氧酸盐抗癌研究应重点解决的几个问题,为进一步研究多金属氧酸盐抗癌药物活性提供了参考。

关键词： 多金属氧酸盐, 抗癌, 生物活性, 化疗药物

Polyoxometalates (POMs) have attracted a considerable attention due to their unique structural characteristics and chemical properties. The research of polyoxometalates as anticancer chemotherapy drugs especially has become inexhaustible motivation to the scholars. Therefore, the anticancer activities of POMs become one of the frontier subjects in this field. This paper summarizes the research progress in the field of anticancer bioactivities of polyoxometalates at home and abroad, including the basis of anti-cancer effect of polyoxometalates, anti-cancer effect in vitro, anti-cancer effect in vivo and the anticancer mechanism of isopoly acid and heteropoly acid with diversiform structured types. It has put forward some solutions to the important problems in anticancer application research of polyoxometalates currently. This paper provides the reference for the anticancer drug research of polyoxometalates. Contents
1 Introduction
2 Basis of anticancer effect of polyoxometalates
2.1 Origin of cancer
2.2 Anticancer active site
3 Anticancer research of polyoxometalates in vitro
3.1 Anticancer effect of isopoly acid in vitro
3.2 Anticancer effect of heteropoly acid in vitro
4 Anticancer research of polyoxometalates in vivo
4.1 Anticancer effect of isopoly acid in vivo
4.2 Anticancer effect of heteropoly acid in vivo
5 Anticancer mechanism of polyoxometalates
6 Conclusion and outlook

Key words: polyoxometalates, anticancer, bioactivities, chemotherapeutics

中图分类号: 

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抗癌多金属氧酸盐