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化学进展 2013, Vol. 25 Issue (06): 975-989 DOI: 10.7536/PC120941 前一篇   后一篇

• 综述与评论 •

共轭聚合物的功能化及在生物/化学分析领域的应用

蔡小慧1, 石琳1, 刘兴奋1,2*, 黄艳琴1,2, 范曲立1,2, 黄维1,2,3,4*   

  1. 1. 南京邮电大学 信息材料与纳米技术研究院 南京 210046;
    2. 有机电子与信息显示国家重点实验室培育基地 南京 210046;
    3. 江苏-新加坡有机电子和信息显示联合实验室 南京 211816;
    4. 南京工业大学 先进材料研究院 南京 211816
  • 收稿日期:2012-09-01 修回日期:2013-03-01 出版日期:2013-06-25 发布日期:2013-05-02
  • 通讯作者: 刘兴奋,黄维 E-mail:iamxfliu@njupt.edu.cn;iamwhuang@njupt.edu.cn
  • 基金资助:

    国家重点基础研究发展计划(973)项目(No.2009CB930601,2012CB933301,2012CB723402);国家自然科学基金项目(No. 21005040,51073078,51173080);江苏高校优势学科建设工程资助项目;“有机与生物光电子学”教育部创新团队项目(No. IRT1148);南京邮电大学物联网重大专项(NY211003)和江苏省普通高校研究生科研创新计划项目(CXLX12_0468)资助

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Functionalized Conjugated Polymers and Their Application in the Biological and/or Chemical Analysis

Cai Xiaohui1, Shi Lin1, Liu Xingfen1,2*, Huang Yanqin1,2, Fan Quli1,2, Huang Wei1,2,3,4*   

  1. 1. Institute of Advanced Materials(IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046, China;
    2. Key Laboratory for Organic Electronics & Information Displays (KLOEID), Nanjing 210046, China;
    3. Jiangsu-Singapore Joint Research Center for Organic/Bio-Electronics & Information Displays, Nanjing 211816, China;
    4. Institute of Advanced Materials, Nanjing University of Technology, Nanjing 211816, China
  • Received:2012-09-01 Revised:2013-03-01 Online:2013-06-25 Published:2013-05-02

共轭聚合物具有电子高度离域的共轭结构及优异的光吸收和发射特性, 在有机电子、化学/生物传感、医学诊断及生物成像等领域具有广泛的应用。特定基团功能化的共轭聚合物含有可特异性识别生物/化学分子的功能基团(如糖基、生物素、羧基、氨基酸、肽段、核酸、抗体、氨基、巯基等),进一步拓宽了共轭聚合物在生物/化学分析领域的应用。本文从功能化基团的不同类别出发, 对近年来共轭聚合物的功能化方法及其在生物/化学分析领域的应用(如蛋白质、病原体、Hg2+、Pb2+检测)进行了综述, 并对该领域的发展前景进行了展望。

关键词： 共轭聚合物, 功能化, 生物传感, 糖基化, 生物素

Conjugated polymers with large, delocalized molecular structure have been widely used in the field of organic electronics, biological and/or chemical sensing, diagnosis and bioimaging due to their unique optical absorption and emission characteristics. Conjugated polymers functionalized by special groups, such as glycosyl, biotin, carboxyl, amino acid, peptide, nucleic acid, antibody, amino, thiol and so on, have ability to recognize certain biomolecules or heavy metal ions. Here, we review the recent development of functionalized conjugated polymer and their application in the biological and/or chemical analysis on the basis of functional groups of different types. Methods for functionalization of conjugated polymers, the application in the detection of proteins, pathogens, Hg2+ and Pb2+, and future development of this area are also included. Contents
1 Introduction
2 Functionalization of conjugated polymers and their application in the biological and/or chemical analysis
2.1 Glycosyl functionalization
2.2 Biotin functionalization
2.3 Carboxyl functionalization
2.4 Functionalized with amino acid, peptide, nucleic acid and antibody
2.5 Functionalized with other groups (amino, thiol, and crown ether)
3 Summary and outlook

Key words: conjugated polymers, functionalization, biosensor, glycosylation, biotin

中图分类号: 

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