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化学进展 2016, Vol. 28 Issue (6): 801-813 DOI: 10.7536/PC160102 前一篇   后一篇

• 综述与评论 •

茚及其衍生物的催化不对称合成

何桥2, 殷中琼3, 陈华保2, 张祖民1, 王显祥1, 乐贵洲1,2*   

  1. 1. 四川农业大学理学院 雅安 625014;
    2. 四川农业大学农学院 成都 611130;
    3. 四川农业大学动物医学院 成都 611130
  • 收稿日期:2016-01-01 修回日期:2016-03-01 出版日期:2016-06-15 发布日期:2016-03-23
  • 通讯作者: 乐贵洲 E-mail:yueguizhou@sicau.edu.cn
  • 基金资助:
    四川省科技厅应用基础项目(No. 2012JY0118)
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Catalytic Asymmetric Syntheses of Indenes and Their Derivatives

He Qiao2, Yin Zhongqiong3, Chen Huabao2, Zhang Zumin1, Wang Xianxiang1, Yue Guizhou1,2*   

  1. 1. College of Science, Sichuan Agricultural University, Ya'an 625014, China;
    2. College of Agricultural Sciences, Sichuan Agricultural University, Chengdu 611130, China;
    3. College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
  • Received:2016-01-01 Revised:2016-03-01 Online:2016-06-15 Published:2016-03-23
  • Supported by:
    The work was supported by the Science & Technology Department of Sichuan Province (No. 2012JY0118) and the "dual support" Project of Sichuan Agricultural University.
茚及其衍生物广泛存在于自然界中,其中多官能团化的茚类化合物大多具有重要的生物活性,因而非常具有成为药物的先导化合物的潜力。特别是茚类化合物的不对称合成吸引了有机化学家们的广泛关注,最近有许多相应的合成方法研究被报道,包括外消旋体拆分、手性辅基及底物诱导的合成和手性催化合成等。本文总结了茚及其衍生物的催化不对称合成研究进展,重点介绍过渡金属及有机小分子不对称催化反应,并对该领域的研究前景进行了展望。
关键词： 茚, 茚酮, 氢化茚, 茚醇, 立体选择性, 不对称合成
Indenes and their derivatives widely exists in natural world, and some of them bearing multi-functional groups are very potential to become the lead compounds in drug because of their important bioactivities. In particular, asymmetric syntheses of indenes have attracted the extensive attention of organic chemists. Recently, many synthetic methods of them have been reported, including resolution of racemic mixture, syntheses of chiral auxiliary or substrate's induction, as well as chiral catalytic synthesis. In this review, we summarize the asymmetric syntheses of these compounds, and focus on the transition metal-catalyzed and organocatalytic asymmetric reaction. Finally, the further research on this field is also discussed.

Contents
1 Introduction
2 Catalytic asymmetric syntheses of indenes and their derivatives
2.1 Indene
2.2 Indanone
2.3 Indane
2.4 Indanol
2.5 Other derivatives
3 Conclusion

Key words: indene, indanone, indane, indanol, stereoselectivity, asymmetric synthesis

中图分类号: 

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摘要

茚及其衍生物的催化不对称合成