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化学进展 2016, Vol. 28 Issue (1): 67-74 DOI: 10.7536/PC150643 前一篇   后一篇

• 综述与评论 •

微纳米粒子的形貌调控及其对药物/基因传递体系的影响

刘亚杰, 张鹏, 杜建委, 王幽香*   

  1. 教育部高分子合成与功能构造重点实验室 浙江大学高分子科学与工程学系 杭州 310027
  • 收稿日期:2015-06-01 修回日期:2015-08-01 出版日期:2016-01-15 发布日期:2015-12-21
  • 通讯作者: 王幽香 E-mail:yx_wang@zju.edu.cn
  • 基金资助:
    国家自然科学基金项目(No.21474087,51273177)资助
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Regulation the Morphology of Micro-and Nanoparticles and the Effect on Drug/Gene Delivery System

Liu Yajie, Zhang Peng, Du Jianwei, Wang Youxiang*   

  1. Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2015-06-01 Revised:2015-08-01 Online:2016-01-15 Published:2015-12-21
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21474087, 51273177).
超分子组装体由于具有适合的微纳米尺寸、可控的结构和良好的生物相容性等特点,极大地促进了药物/基因传递体系的发展。拓扑结构(如形貌、尺寸)是影响药物/基因传递体系的重要因素,这方面研究正成为这一领域的研究热点。本文综述了调控组装体形貌的主要手段,包括聚合物链结构与组成、组装条件、外界刺激及聚合诱导的组装体形貌,初步探讨了微观形貌对药物/基因传递体系的影响,并对这一领域进行了展望。
关键词： 微纳米粒子, 自组装, 形貌调控, 药物/基因载体
Supramolecular assembly has greatly promoted the development of drug/gene delivery system, due to the suitable micrometer or nanometer size, controllable structure and excellent biocompatibility. Recent studies have found that the topological structure plays a critical role in the drug/gene delivery process, which attracts great interest of researchers. In this paper, the main factors that regulate the morphology of micro-and nanoparticles are discussed, which mainly include composition of the copolymer, condition of self-assembly, external stimuli and polymerization-induced self-assembly. Then the effect of morphology on drug/gene delivery, challenges and prospects in this area are also discussed at the end of this review.

Contents
1 Introduction
2 Main methods of morphology regulation
2.1 Effect of the copolymer composition
2.2 Effect of self-assembly condition
2.3 Effect of external stimuli
2.4 Polymerization-induced self-assembly
3 The effect of morphology of drug/gene delivery system on blood circulation time and cell uptake
4 Conclusion

Key words: micro-and nanoparticles, self-assembly, morphology regulation, drug/gene vector

中图分类号: 

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