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化学进展 2017, Vol. 29 Issue (7): 757-765 DOI: 10.7536/PC170351 前一篇   后一篇

• 综述 •

疏水缔合水凝胶

牛娜, 李志英, 高婷婷, 刘玉东, 刘晓丽, 刘凤岐*   

  1. 吉林大学化学学院 长春 130012
  • 收稿日期:2017-03-31 修回日期:2017-06-01 出版日期:2017-07-15 发布日期:2017-06-22
  • 通讯作者: 刘凤岐 E-mail:liufengqi@jlu.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.21174053）资助
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Hydrophobic Association Hydrogel

Na Niu, Zhiying Li, Tingting Gao, Yudong Liu, Xiaoli Liu, Fengqi Liu*   

  1. College of Chemistry, Jilin University, Changchun 130012, China
  • Received:2017-03-31 Revised:2017-06-01 Online:2017-07-15 Published:2017-06-22
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21174053).
疏水缔合水凝胶是指由疏水相互作用形成的物理交联型水凝胶。由于具有传统化学交联型凝胶所不具备的高机械强度、自愈合和二次加工的特性,疏水缔合水凝胶的合成制备、结构优化、性能调控和应用拓展逐渐成为凝胶材料领域的研究热点。作为网络交联点的疏水缔合微区存在动态可逆的缔合-解缔合平衡,这是疏水缔合水凝胶的亮点,也是网络构筑、机理探讨以及性能改进的切入点和关键所在。疏水缔合水凝胶具有敏感度高、智能响应和生物相容等优点,广泛应用于智能材料和生物载体等领域。本文从结构组成出发,介绍了具有不同结构类型的疏水缔合水凝胶,并结合制备方法,总结出其性能各异的成因及机理,对研究现状及应用价值进行了归纳和展望。
关键词： 疏水缔合, 物理交联, 胶束聚合, 高机械强度, 自愈合
Hydrophobic association hydrogels (HA-gels) have physical crosslinking networks, which are generated via hydrophobic association. The synthesis methods, structure optimization, property modulation and applications of HA-gels are becoming hot topics in gel materials. This is because HA-gels have many merits such as high mechanical strength, self healing, secondary processing and so on compared with chemical crosslinking hydrogels. In addition, as network crosslinking points, hydrophobic association domains contain dynamic and reversible association-dissociation balance (RADB). It is worth mentioning that, RADB is not only the highlight of HA-gels, but also the hitting-point and the key of network construct, mechanism study and performance improvement. With advantages of high sensitivity, smart response and biocompatibility, HA-gels have shown promising applications in a lot of fields, including smart materials, biology, medicine, and so on. Therefore, in the review, we begin with structure composition of HA-gels, introduce different structure and synthesis methods of them, and then summarize the cause and mechanism of the differences in properties. At last, the present research status is concluded and the application prospect of HA-gels is outlooked as well.
Contents
1 Introduction
2 Structural composition
2.1 Block hydrophobic association hydrogels
2.2 Coiled-coil peptides hydrophobic association hydrogels
3 Synthesis methods
3.1 Free radical polymerization
3.2 Chemical modification on matrix
4 Performance evaluation
4.1 Mechanical property
4.2 Swelling behavior
4.3 Self healing property
5 Promising applications
5.1 Biology and medicine
5.2 Smart materials
5.3 Oilfield exploitation
6 Conclusion and outlook
Key words: hydrophobic association, physical crosslink, micelle polymerization, high mechanical strength, self-healing

中图分类号: 

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疏水缔合水凝胶