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化学进展 2005, Vol. 17 Issue (01): 130-136 前一篇   后一篇

• 综述与评论 •

多肽定量构效关系与分子设计

丁俊杰 丁晓琴* 赵立峰 陈冀胜   

  1. (北京药物化学研究所 北京102205)
  • 收稿日期:2003-11-01 修回日期:2004-07-01 出版日期:2005-01-24 发布日期:2005-01-24
  • 通讯作者: 丁晓琴 E-mail:dingxq @cetin. net. cn

Recent Advances of the Perfluoroalkylsulfonate and Bis-(perfluoroalkylsulfonyl) imide Complexes in Heterogeneous Catalysis

Ding Junjie  Ding Xiaoqin*   Zhao Lifeng  Chen Jisheng   

  1. (Beijing Institute of Pharmaceutial Chemistry , Beijing 102205 , China)
  • Received:2003-11-01 Revised:2004-07-01 Online:2005-01-24 Published:2005-01-24
  • Contact: Ding Xiaoqin E-mail:dingxq @cetin. net. cn

综述了多肽定量构效关系和计算机辅助多肽分子设计方法的最新进展,重点介绍了多肽定量构效关系研究中的化学结构定量描述符和建立数学模型的统计方法,并对模拟肽学和虚拟组合多肽库在多肽分子设计中的应用进行了简要的论述。

Conventional Lewis acid catalysts are now of great challenge especially in relation to today' s environmen-tal concerns. The use of perfluoroalkylsulfonate and bis(perfluoroalkylsulfonyl)imide complexes as homogeneous and high-efficient Lewis acid catalysts in organic synthesis has been the subject of numerous publications. For the simplifications of separation and isolation, the immobilized homogeneous catalysts have been made great progress. Recent advances of the perfluoroalkylsulfonate and bis(perfluoroalkylsulfonyl)imide complexes in heterogeneous catalysis and its preparation and activity when immobilized by organic supports, inorganic supports and ion liquids are reviewed, and the prospect for the heterogeneous catalysts is also proposed.

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摘要

多肽定量构效关系与分子设计