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化学进展 2004, Vol. 16 Issue (04): 574- 前一篇   后一篇

• 综述与评论 •

路易斯酸碱催化的外消旋体(动态)动力学拆分反应

张占金1,2 毛金城2 万伯顺2 陈惠麟2   

  1. (1.渤海大学化学与食品科学学院 锦州 121000; 2.中国科学院大连化学物理研究所 大连 116023)
  • 收稿日期:2003-03-01 修回日期:2003-07-01 出版日期:2004-07-26 发布日期:2004-07-26
  • 通讯作者: 张占金
下载PDF ( 1819 ) 引用
导出 被引次数 ( 27 | 2 )

(Dynamic) Kinetic Resolution Reactions of Racemes Catalyzed by Lewis Acid and Base Catalysts

Zhang Zhanjin1,2;Mao Jincheng2;Wan Boshun2;Chen Huilin2   

  1. (1.College of Chemistry and Food Science, Bohai University, Jinzhou 121000; 2.Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023)
  • Received:2003-03-01 Revised:2003-07-01 Online:2004-07-26 Published:2004-07-26
  • Contact: Zhang Zhanjin
外消旋体的(动态)动力学拆分反应是制备手性化合物的重要方法之一.反应可以通过酶催化或非酶催化的手段来实现,也可以通过两种方法的有机结合来进行.在非酶催化反应中,路易斯酸碱催化是比较常用的方法,它们被广泛地用于多种外消旋体的(动态)动力学拆分反应中,目前在该领域取得了很大的进展.本文讨论了路易斯酸及路易斯碱催化体系在外消旋体(动态)动力学拆分反应中应用的最新进展.
关键词： 路易斯酸碱, 外消旋体, (动态)动力学拆分, 非酶催化
The (dynamic) kinetic resolution of raceme is one of the important ways in the synthesis of chiral com-pounds. The reaction can be realized by enzymatic or non-enzymatic catalysis or by combination of two methods. The cat-alytic systems of Lewis acid and base are useful ways in the non-enzymatic catalysis. They were widely used to different kinds of (dynamic) kinetic resolution reactions. At present, mighty advances have been made in the field. Recent progress in the applications of non-enzymatic system about Lewis acid and base to (dynamic)kinetic resolution reactions of racemes is reviewed.
Key words: Lewis acid and base, raceme, (dynamic)kinetic resolution, non-enzymatic catalysis

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