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化学进展 2011, Vol. 23 Issue (7): 1485-1492 前一篇   后一篇

• 放射化学专辑 •

国内心、脑、肿瘤放射性诊断药物的研究进展

曾华辉, 张华北*   

  1. 放射性药物教育部重点实验室 北京师范大学化学学院 北京 100875
  • 收稿日期:2011-01-01 修回日期:2011-04-01 出版日期:2011-07-24 发布日期:2012-03-15
  • 通讯作者: e-mail: hbzhang@bnu.edu.cn E-mail:hbzhang@bnu.edu.cn
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Advances in Domestic Brain, Heart, Tumor Radioactive Diagnosis Drugs

Zeng Huahui, Zhang Huabei*   

  1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
  • Received:2011-01-01 Revised:2011-04-01 Online:2011-07-24 Published:2012-03-15

近年来,我国放射性药物的发展很迅速,并且在医学诊治疾病中及基础研究中占据越来越重要的地位。放射性诊断药物是指用于体内进行医学诊断的含放射性核素标记的化合物或生物制剂。本文介绍了国内近年放射性诊断药物在神经系统、心血管、肿瘤等方面的研究进展和应用前景,并提出了目前国内放射性药物研究存在的主要问题和今后可能的发展方向: 大力发展PET药物,重点是设计和研制各类脑受体显像剂、有特异性受体结合的肿瘤显像剂和心肌代谢显像剂等。

关键词： 放射性药物, 显像剂, 诊断和治疗放射性药物, PET

In recent years, radiopharmaceutical has played an increasingly important role in the medical diagnosis and treatment of diseases and the fundamental research of medicine, with the rapid development of the radiopharmaceutical. A diagnosis radiopharmaceutical is a biological agent or small molecule labeled with radioactive nuclide, which is applied in medical diagnosis of diseases in vivo. In this paper, a brief introduction to domestic recent development and applications of diagnosis radiopharmaceutical in the nervous system, cardiovascular and tumor imaging is given. Some main existing problems in the research of radiopharmaceuticals are advanced and the new research aspects may be provided in the coming years. We should devote major efforts to developing the PET tracer in our country, and the key aspect is to design and develop all kinds of the brain receptors imaging agents, receptor binding tumor imaging agents, the myocardium metabolism imaging agents and so on. These developments and achievements of radiopharmaceuticals to improve the peoples health are highly significant in our country.

Contents
1 Introduction
2 Development of nervous system imaging agent
3 Development of cardiovascular imaging agent
4 Development of tumor imaging agent
5 Outlook

Key words: radiopharmaceuticals, imaging agent, diagnostis and therapeutic radiopharmaceuticals, PET

中图分类号: 

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