[Objective/Significance] As an important link in implementing the innovation driven strategy and building an innovative country, the construction of regional innovation system is of great significance to carry out innovation construction by clarifying the development status of regional innovation system and exploring the development direction of regional innovation system. [Method/Process] Using CiteSpace software, this paper makes a visual bibliometric analysis of the core documents under the theme of regional innovation system included in CSSCI database during 2000-2020 from the aspects of the number of documents, journals, organization distribution, author distribution and keyword clustering. [Rseults/Conclusions] According to the research content and heat, the domestic research on regional innovation system is divided into three stages: start, growth and maturity. The three stages have continuity and characteristics of the times in the research content and research methods. At the same time, it is found that China’s research on regional innovation system has the characteristics of policy sensitivity, discipline singleness and institutional space aggregation. Therefore, In the future, the research should be based on China’s national conditions, grasp the policy trend, strengthen cooperation between institutions and expand the research field.