As computer chips are developing smaller and more compact driven by industry, graphene and other two-dimensional materials are considered to be one of the greatest candidates, and enable electronic devices to extend or surpass Moore's law. Compared to other scientific literatures such as journal papers and patents, funded projects are more time-sensitive, prospective, and strategic, and National Science Foundation (NSF) is currently one of the most representative and influential science funding agency in the world. Based on NSF funded project data, this paper studies the development trend of two-dimensional materials research domain by using bibliometrics and text analysis methods. The analysis conclusions include: graphene related funded projects are dominant compared with non-graphene related two-dimensional materials funded projects, the non-graphene related funded projects have increased obviously since 2014; the research priorities of graphene and non-graphene related two-dimensional materials are not identical, and graphene related funded projects focus on low cost, stable and efficient fabrication of electrodes, electron theory study of condensed matter physics and high performance applications in sensors and detection, while non-graphene related funded projects focus on theoretical research of novel information technology, synthesis methods, manufacturing tools and mass production of materials and devices; the two-dimensional material research topics are developing from material preparation and physical properties to device fabrication and industrial application; in addition, NSF funded project in two-dimensional materials field also focuses on cross-domain integration research and next-generation talents education. This paper provides some insights for two-dimensional materials involved basic research and frontier science management.