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化学进展 2016, Vol. 28 Issue (9): 1397-1405 DOI: 10.7536/PC160423 前一篇   后一篇

• 综述与评论 •

增强纳米药物载体肿瘤内渗透分布的研究进展

韩冬琳1, 亓洪昭1, 赵瑾1, 龙丽霞1, 任玉2, 原续波1*   

  1. 1. 天津大学材料科学与工程学院 天津市材料复合与功能化重点实验室 天津 300072;
    2. 天津医科大学基础医科研究中心 天津 300070
  • 收稿日期:2016-04-01 修回日期:2016-06-01 出版日期:2016-09-15 发布日期:2016-08-16
  • 通讯作者: 原续波 E-mail:xbyuan@tju.edu.cn
  • 基金资助:
    国家自然科学基金项目（No.51303125，51473119）资助
下载PDF ( 1328 ) 引用
被引次数 ( 2 | 1 )

Enhancement of Intra-Tumor Penetration and Distribution of Nano-Drug Carriers

Han Donglin1, Qi Hongzhao1, Zhao Jin1, Long Lixia1, Ren Yu2, Yuan Xubo1*   

  1. 1. Tianjin Key Laboratory of Composite & Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 30007;
    2. Basic Medical Research Center, Tianjin Medical University, Tianjin 300070, China
  • Received:2016-04-01 Revised:2016-06-01 Online:2016-09-15 Published:2016-08-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 51303125,51473119).
利用纳米载体负载小分子化疗药物、蛋白和基因有助于降低这些药物的毒副作用，在肿瘤治疗中发挥着重要作用。然而，由于肿瘤独特的病理生理学特点，纳米药物载体在肿瘤中的分布并不均匀，无法有效渗透到肿瘤深部，使药物的疗效受到限制。通过控制纳米药物载体的粒径、表面电位、表面功能基团和形状等理化性质，可以实现其在肿瘤组织中的有效扩散。本文从无机和有机纳米药物载体两个体系出发，综述了通过对纳米药物载体的组成、结构设计和理化性质的调控，促进其在肿瘤组织中均匀分布及深度渗透的研究进展，并展望了面临的挑战和可能的解决途径。
关键词： 纳米药物载体, 理化性质, 肿瘤, 渗透, 微观分布
The tumor therapeutics effect of chemotherapeutant, proteins and genes could be improved when they are loaded in nano-drug carriers. But in some cases the therapeutics effects are modest due to the poor penetration and distribution of nano-carriers in the heterogeneous tumor tissue. During the recent years, increasing efforts have been dedicated to improve the intra-tumor penetration by controlling the size, surface zeta potential, targeting agents, and shape of nano-drug carriers. This paper reviews the progress in enhancement of intra-tumor penetration and distribution of nano-drug carriers through the modification of their components, structures and physicochemical properties. The challenges of nano-drug carriers in tumor treatment are raised and the possible solutions are proposed.

Contents
1 Introduction
2 Inorganic nano-drug carriers
2.1 Meso-porous silicon nano-drug carriers
2.2 Gold nano-drug carriers
3 Organic nano-drug carriers
3.1 Micelles
3.2 Dendrimers
3.3 Liposomes
3.4 Polymer nanocapsule
4 Conclusion

Key words: nano-drug carriers, physicochemical properties, tumor, penetration, microscopic distribution

中图分类号: 

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