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化学进展 2016, Vol. 28 Issue (8): 1224-1237 DOI: 10.7536/PC151137 前一篇   后一篇

• 综述与评论 •

近紫外光辅助4-硫脱氧胸苷抗癌作用的研究

蒋革1, 罗锋1, 徐耀忠2, 张晓辉3*   

  1. 1. 大连大学生命科学与技术学院 大连 116622;
    2. Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK;
    3. 大连大学环境与化学工程学院 大连 116622
  • 收稿日期:2015-11-01 修回日期:2016-05-01 出版日期:2016-08-15 发布日期:2016-07-12
  • 通讯作者: 张晓辉 E-mail:xiaohui99@hotmail.co.uk
  • 基金资助:
    教育部留学回国人员科研启动基金

UVA Assisted 4-Thiothymidine for Cancer Treatment

Jiang Ge1, Luo Feng1, Xu Yaozhong2, Zhang Xiaohui3*   

  1. 1. School of Life Science and Biotechnology, Dalian University, Dalian 116622;
    2. Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, MK7 6AA, UK;
    3. College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China
  • Received:2015-11-01 Revised:2016-05-01 Online:2016-08-15 Published:2016-07-12
  • Supported by:
    The work was supported by the Research and Start Fund of the Ministry of Education
4-硫脱氧胸苷(4-thiothymidine, STdR)作为硫代类核苷类似物的典型代表,其具有较强的亲脂特性和强的紫外长波长(315~400 nm,UVA)吸收。这些特性使得4-硫脱氧胸苷能够靶向进入肿瘤细胞并以核苷酸的形式嵌入DNA链中,在近紫外UVA的辅助下发生光化学反应,损伤肿瘤细胞DNA,诱导细胞走向凋亡途径,达到抗癌的目的。本文系统地介绍和评述了长波紫外光/含硫脱氧胸苷(UVA/thiothymidine)的抗癌疗法及原理,探讨4-硫脱氧胸苷与人血清蛋白间的相互作用,为这种新型光化学疗法在今后的癌症治疗中提供基础的理论依据。
This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized. As the chemical structure of 4-thiothymidine is very similar to that of its parent thymidine, thus 4-thiothymidine can be readily incorporated into cellular DNA, and with the help of thymidine kinase, much more preferably into cancerous DNA. Unlike thymidine, 4-thiothymdine can absorb strongly in UVA (longer wavelengths of UV) light. Thus UVA-assisted 4-thiothymidine offers an effective cancer treatment. Some underlying mechanisms of action by 4-thiothymidine/UVA and compares this cancer approach with the commonly used photodynamic therapy are discussed. The various interactions between 4-thiothymidine with human serum albumin are introduced. Finally, a short conclusion on the past efforts and a brief prospect for future work in this exciting research field are given.

Contents
1 Introduction
2 Key properties of 4-thiothymidine
3 Synthetic chemistry and photochemistry of 4-thiothymidine
3.1 Synthetic chemistry of 4-thiothymidine
3.2 Photochemistry of 4-thiothymidine under UVA irradiation
4 Antitumor activity of 4-thiothymidine under UVA irradiation
4.1 Cytotoxicity of 4-thiothymidine
4.2 Synergistic toxicity of 4-thiothymidine with UVA irradiation
4.3 UVA assisted 4-thiothymidine for cancer treatment
4.4 UVA assisted 4-thiothymidine versus photodynamic therapy
5 Antitumor mechanisms of UVA assisted 4-thiothymidine
5.1 Cellular incorporation of 4-thiothymidine
5.2 Principles of tumor-killing via UVA assisted 4-thiothymidine
5.3 Induced apoptosis via UVA assisted 4-thiothymidine
5.4 4-Thiothymidine metabolism
6 4-Thiothymidine stability in blood circulation
6.1 Spectrometry
6.2 Atomic force microscope
6.3 Molecular docking
7 Conclusion

中图分类号: 

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