English
新闻公告
More
化学进展 2012, Vol. 24 Issue (04): 606-615 前一篇   后一篇

• 综述与评论 •

多环麝香(PCMs)的环境行为及毒性效应

李卓娜, 周群芳, 刘稷燕, 史亚利, 蔡亚岐, 江桂斌   

  1. 环境化学与生态毒理学国家重点实验室 中国科学院生态环境研究中心 北京 100085
  • 收稿日期:2011-08-01 修回日期:2011-09-01 出版日期:2012-04-24 发布日期:2012-02-08
  • 基金资助:

    国家自然科学基金项目(No.20837003);国家高技术发展计划(863)项目(No.2009CB21605)资助

Environmental Behavior and Toxicological Effects of Polycyclic Musks

Li Zhuona, Zhou Qunfang, Liu Jiyan, Shi Yali, Cai Yaqi, Jiang Guibin   

  1. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
  • Received:2011-08-01 Revised:2011-09-01 Online:2012-04-24 Published:2012-02-08
多环麝香(PCMs)作为重要的人工合成麝香广泛应用于日用品中,目前在各种环境介质中都能检测到PCMs的存在。由于其持续不断地进入环境并能够在生物体内积累,其效应类似于持久性污染物。作为一类新型污染物,PCMs所引起的环境问题受到了广泛重视。本文介绍了PCMs的物理化学性质、来源以及在不同环境介质中的分析方法和污染现状,概述了其在环境中的降解转化、生物富集行为,并总结了其能产生的急性毒性效应、亚慢性毒性效应、内分泌干扰效应和其他潜在的毒性效应,最后讨论了目前研究中存在的问题,并对未来研究进行了展望。今后,应该建立有效的、可比对的标准分析方法,更加系统地进行环境污染现状、迁移转化规律和生物降解代谢途径的研究;重视暴露途径和生物有效性的研究,并与风险评价结合;结合环境中PCMs的污染现状,探讨低剂量长期暴露和复合暴露对生物的影响。
Polycyclic musks (PCMs) are important synthetic fragrances widely used in personal care products. Due to their continuous release into the environment and bioaccumulation, environmental behaviors of PCMs are similar to persistent organic pollutants. PCMs are new emerging pollutants and have attracted remarkable attention due to their ubiquitous distribution in the environment. In this paper, the characteristics, pollution sources, analytical methods and pollution status of PCMs are described. Then the degradation, transformation and bioaccumulation are summarized. Toxicological effects such as acute toxicity, subchronic toxicity, endocrine disrutpting toxicity and other potential toxic effects are also introduced. Finally, the existing problems and future research directions are proposed. In the future, standard analytical methods should be established to systematically understand pollution situation, migration and transformation law, and metabolic pathways of PCMs. The impacts of PCMs exposure pathways on bioavailability should also be investigated to assess potential risks. In addition, studies are also needed to explore single and combined toxic effects of PCMs at long-term low-dose exposure in vivo assay.
Contents
1 Introduction
2 Physical and chemical properties
3 Sources of PCMs in environment
4 Analytical methods
4.1 Sample extraction
4.2 Sample clean-up
4.3 Sample analysis
5 The pollution status of PCMs in environment
5.1 PCMs in water
5.2 PCMs in sewage sludge and sediment
5.3 PCMs in human being
5.4 PCMs in biota
5.5 PCMs in air
6 Degradation and transformation
7 Bioaccumulation
8 Toxicological effects
8.1 Acute toxicological effects
8.2 Subchronic toxicological effects
8.3 Other toxicological effects
8.4 Endocrine disrupting effects
9 Conclusion and prospects

中图分类号: 

()
[1] Reiner J L, Kannan K. Chemosphere, 2006, 62: 867-873
[2] Roosens L, Covaci A, Neels H. Chemosphere, 2007, 69: 1540-1547
[3] Zhang X L, Yao Y, Zeng X Y, Qian G R, Guo Y W, Wu M H, Sheng G Y, Fu J M. Chemosphere, 2008, 72: 1553-1558
[4] Bester K. Chemosphere, 2004, 57: 863-870
[5] Draisci R, Marchiafava C, Ferretti E, Palleschi L, Catellani G, ANastasio A. J. Chromatogr. A, 1998, 814: 187-197
[6] Fromme H, Otto T, Pilz K, Neugebauer F. Chemosphere, 1999, 39: 1723-1735
[7] Gatermann R, Hellou J, Huhnerfuss H, Rimkus G, Zitko V. Chemosphere, 1999, 38: 3431-3441
[8] Kuhlich P, Gostl R, Teichert P, Piechotta C, Nehls I. Anal. Bioanal. Chem., 2011, 399: 3579-3588
[9] Balk F, Ford R A. Toxicol. Lett., 1999, 111: 81-94
[10] Salvito D. Environ. Health Perspect., 2005, 113: A802-A803
[11] Chen X J, Pauly U, Rehfus S, Bester K. Chemosphere, 2009, 76: 1094-1101
[12] Schiavone A, Kannan K, Horii Y, Focardi S, Corsolini S. Mar. Pollut. Bull., 2009, 58: 1415-1419
[13] Schiavone A, Kannan K, Horii Y, Focardi S, Corsolini S. Environ. Pollut., 2010,158: 599-606
[14] Sumner N R, Guitart C, Fuentes G, Readman J W. Environ. Pollut., 2010, 158: 215-222
[15] Wang Y C, Ding W H. J. Chromatogr. A, 2009, 1216: 6858-6863
[16] Zeng X Y, Lin Z, Gui H Y, Shao W L, Sheng G Y, Fu J M, Yu Z Q. Environ. Monit. Assess., 2010, 169: 89-100
[17] Heberer T. Acta Hydrochim. Hydrobiol., 2003, 30: 227-243
[18] Balk F, Ford R A. Toxicol. Lett., 1999, 111: 57-79
[19] Joss A, Keller E, Alder A C, Gobel A, McArdell C S, Ternes T, Siegrist H. Water Res., 2005, 39: 3139-3152
[20] Artola-Garicano E, Borkent I, Damen K, Jager T, Vaes W H J. Environ. Sci. Technol., 2003, 37: 116-122
[21] Carballa M, Omil F, Lema J M, Llompart M, Garcia-Jares C, Rodriguez I, Gomez M, Ternes T. Water Res., 2004, 38: 2918-2926
[22] Kupper T, Berset J D, Etter-Holzer R, Furrer R, Tarradellas J. Chemosphere, 2004, 54: 1111-1120
[23] Osemwengie L I, Steinberg S. J. Chromatogr. A, 2001, 932: 107-118
[24] Rimkus G G. Toxicol. Lett., 1999, 111: 37-56
[25] Simonich S L, Federle T W, Eckhoff W S, Rottiers A, Webb S, Sabaliunas D, de Wolf W. Environ. Sci. Technol., 2002, 36: 2839-2847
[26] Horii Y, Reiner J L, Loganathan B G, Kumar K S, Sajwan K, Kannan K. Chemosphere, 2007, 68: 2011-2020
[27] Reiner J L, Kannan K. Water, Air, Soil Pollut., 2011, 214: 335-342
[28] Dsikowitzky L, Schwarzbauer J, Kronimus A, Littke R. Chemosphere, 2004, 57: 1275-1288
[29] Dsikowitzky L, Schwarzbauer J, Littke R. Org. Geochem., 2002, 33: 1747-1758
[30] Ternes T A, Herrmann N, Bonerz M, Knacker T, Siegrist H, Joss A. Water Res., 2004, 38: 4075-4084
[31] Llompart M, Garcia-Jares C, Salgado C, Polo M, Cela R. J. Chromatogr. A, 2003, 999: 185-193
[32] Yang J J, Metcalfe C D. Sci. Total Environ., 2006, 363: 149-165
[33] Stevens J L, Northcott G L, Stern G A, Tomy G T, Jones K C. Environ. Sci. Technol., 2003, 37: 462-467
[34] Difrancesco A M, Chiu P C, Standley L J, Allen H E, Salvito D T. Environ. Sci. Technol., 2004, 38: 194-201
[35] Eschke H D, Traud J, Dibowski H J. Vom Wasser., 1994, 83: 373-383
[36] Zhou H D, Huang X, Gao M J, Wang X L, Wen X H. Journal of Environmental Sciences-China, 2009, 21: 561-567
[37] Artola-Garicano E, Borkent I, Hermens J L M, Vaes W H J. Environ. Sci. Technol., 2003, 37: 3111-3116
[38] Regueiro J, Llompart M, Garcia-Jares C, Garcia-Monteagudo J C, Cela R. J. Chromatogr. A, 2008, 1190: 27-38
[39] Moeder M, Schrader S, Winkler U, Rodil R. J. Chromatogr. A, 2010, 1217: 2925-2932
[40] Einsle T, Paschke H, Bruns K, Schrader S, Popp P, Moeder M. J. Chromatogr. A, 2006, 1124: 196-204
[41] Hu Z, Shi Y, Cai Y. Anal. Chem., 2010, 38: 885-888
[42] Smyth S A, Lishman L, Alaee M, Kleywegt S, Svoboda L, Yang J J, Lee H B, Seto P. Chemosphere, 2007, 67: 267-275
[43] Tadeo J L, Sanchez-Brunete C, Miguel E. J. Chromatogr. A, 2007, 1148: 219-227
[44] Kannan K, Reiner J L, Yun S H, Perrotta E E, Tao L, Johnson-Restrepo B, Rodan B D. Chemosphere, 2005, 61: 693-700
[45] 梁高锋(Liang G F),王珺(Wang J),周静(Zhou J),张晓岚(Zhang X L),盛国英(Sheng G Y),傅家谟(Fu J M). 环境化学(Environmental Chemistry), 2010, 29(1): 113-116
[46] 胡正君(Hu Z J),史亚利(Shi Y L),蔡亚岐(Cai Y Q). 环境化学(Environmental Chemistry), 2010, 29(3): 530-535
[47] Xie Z Y, Ebinghaus R, Temme C, Heemken O, Ruck W G. Environ. Sci. Technol., 2007, 41: 5654-5659
[48] Peck A M, Hornbuckle K C. Atmos. Environ., 2006, 40: 6101-6111
[49] Regueiro J, Garcia-Jares C, Llompart M, Lamas J P, Cela R. J. Chromatogr. A, 2009, 1216: 2805-2815
[50] Bester K. J. Chromatogr. A, 2009, 1216: 470-480
[51] Muller S, Schmid P, Schlatter C. Chemosphere, 1996, 33: 17-28
[52] Zehringer M, Herrmann A. Eur. Food Res. Technol., 2001, 212: 247-251
[53] Stackelberg P E, Furlong E T, Meyer M T, Zaugg S D, Henderson A K, Reissman D B. Sci. Total Environ., 2004, 329: 99-113
[54] Kallenborn R, Gatermann R, Planting S, Rimkus G G, Lund M, Schlabach M, Burkow I C. J. Chromatogr. A, 1999, 846: 295-306
[55] Berset J D, Kupper T, Etter R, Tarradellas J. Chemosphere, 2004, 57: 987-996
[56] Bester K. J. Environ. Monit., 2005, 7: 43-51
[57] Quednow K, Puttmann W. Clean-Soil Air Water, 2008, 36: 70-77
[58] Buerge I J, Buser H R, Muller M D, Poiger T. Environ. Sci. Technol., 2003, 37: 5636-5644
[59] Reiner J L, Berset J D, Kannan K. Arch. Environ. Contam. Toxicol., 2007, 52: 451-457
[60] Herren D, Berset J D. Chemosphere, 2000, 40: 565-574
[61] Zeng X Y, Sheng G Y, Xiong Y, Fu J M. Chemosphere, 2005, 60: 817-823
[62] Guo R, Lee I S, Kim U J, Oh J E. Sci. Total Environ., 2010, 408: 1634-1639
[63] Schmid P, Kohler M, Gujer E, Zennegg M, Lanfranchi M. Chemosphere, 2007, 67: S16-S21
[64] Hutter H P, Wallner P, Hartl W, Uhl M, Lorbeer G, Gminski R, Mersch-Sundermann V, Kundi M. Int. J. Hyg. Envir. Heal., 2010, 213: 124-130
[65] Hu Z, Shi Y, Niu H, Cai Y, Jiang G, Wu Y. Environ. Toxicol. Chem., 2010, 29: 1877-1882
[66] Rimkus G G, Wolf M. Chemosphere, 1996, 33: 2033-2043
[67] Ricking M, Schwarzbauer J, Hellou J, Svenson A, Zitko V. Mar. Pollut. Bull., 2003, 46: 410-417
[68] Lee I S, Lee S H, Oh J E. Water Res., 2010, 44: 214-222
[69] Hu Z, Shi Y, Cai Y. Chemosphere, 2011, 84: 1630-1635
[70] Bester K, Huhnerfuss H, Lange W, Rimkus G G, Theobald N. Water Res., 1998, 32: 1857-1863
[71] Heim S, Schwaubauer J, Kronimus A, Littke R, Woda C, Mangini A. Org. Geochem., 2004, 35: 1409-1425
[72] Peck A M, Linebaugh E K, Hornbuckle K C. Environ. Sci. Technol., 2006, 40: 5629-5635
[73] Cadby P A, Troy W R, Vey M G H. Regul. Toxicol. Pharm., 2002, 36: 246-252
[74] Zeng X Y, Mai B X, Sheng G Y, Luo X J, Shao W L, An T C, Fu J. Environ. Toxicol. Chem., 2008, 27: 18-23
[75] Kronimus A, Schwarzbauer J, Dsikowitzky L, Heim S, Littke R. Water Res., 2004, 38: 3473-3484
[76] Hutter H P, Wallner P, Moshammer H, Hartl W, Sattelberger R, Lorbeer G, Kundi M. Chemosphere, 2005, 59: 487-492
[77] Lignell S, Darnerud P O, Aune M, Cnattingius S, Hajslova J, Setkova L, Glynn A. Environ. Sci. Technol., 2008, 42: 6743-6748
[78] Shek W M, Murphy M B, Lam J C, Lam P K. Mar. Pollut. Bull., 2008, 57: 373-380
[79] Osemwengie L I, Gerstenberger S L. J. Environ. Monit., 2004, 6: 533-539
[80] Duedahl-Olesen L, Cederberg T, Pedersen K H, Hojgard A. Chemosphere, 2005, 61: 422-431
[81] Fromme H, Lahrz T, Piloty M, Gebhart H, Oddoy A, Ruden H. Indoor Air, 2004, 14: 188-195
[82] Peck A M, Hornbuckle K C. Environ. Sci. Technol., 2004, 38: 367-372
[83] Calza P, Sakkas V A, Medana C, Islam M A, Raso E, Panagiotou K, Albanis T. Applied Catalysis B-Environmental, 2010, 99: 314-320
[84] Gatermann R, Biselli S, Huhnerfuss H, Rimkus G G, Hecker M, Karbe L. Arch. Environ. Contam. Toxicol., 2002,42: 437-446
[85] Litz N T, Muller J, Bohmer W. J. Soil. Sediment., 2007, 7: 36-44
[86] Spencer P S, Sterman A B, Horoupian D S, Foulds M M. Science, 1979, 204: 633-635
[87] Ford R A. Dtsch. Lebensm-Rundsch., 1998, 94: 268-275
[88] Api A M, Ford R A. Toxicol. Lett., 1999, 111: 143-149
[89] Steinberg P, Fischer T, Arand M, Park E, Elmadfa I, Rimkus G, Brunn H, Dienes H P. Toxicol. Lett., 1999, 111: 151-160
[90] Gooding M P, Newton T J, Bartsch M R, Hornbuckle K C. Arch. Environ. Contam. Toxicol., 2006, 51: 549-558
[91] Wollenberger L, Breitholtz M, Kusk K O, Bengtsson B E. Sci. Total Environ., 2003, 305: 53-64
[92] Hopkins M N, Lambrert A H. Report RFA/5195 to the Research Institute for Fragrance Materials. 1996
[93] Api A M, Smith R L, Pipino S, Marczylo T, de Matteis F. Food Chem. Toxicol., 2004, 42: 791-801
[94] Steinberg P, Zschaler I, Thom E, Kuna M, Wust G, Schafer-Schwebel A, Weisse G, Kramer P J, Weie G. Arch. Toxicol., 2001, 75: 562-568
[95] Breitholtz M, Wollenberger L, Dinan L. Aquat. Toxicol., 2003, 63: 103-118
[96] Pedersen S, Selck H, Salvito D, Forbes V. Ecotox. Environ. Safe., 2009, 72: 1190-1199
[97] Ramskov T, Selck H, Salvito D, Forbes V E. Environ. Toxicol. Chem., 2009, 28: 2695-2705
[98] Skladanowski A C, Stepnowski P, Kleszczynski K, Dmochowska B. Environ. Toxicol. Pharmacol., 2005, 19: 291-296
[99] Schnell S, Martin-Skilton R, Fernandes D, Porte C. Environ. Sci. Technol., 2009, 43: 9458-9464
[100] Luckenbach T, Ilaria C, Epel D. Mar. Environ. Res., 2004, 58: 215-219
[101] Chen C H, Zhou Q X, Bao Y Y, Li Y N, Wang P. Journal of Environmental Sciences-China, 2010, 22: 1966-1973
[102] Chen C H, Zhou Q X, Cai Z, Wang Y Y. Arch. Environ. Contam. Toxicol., 2010, 59: 564-573
[103] Christian M S, Parker R M, Hoberman A M, Diener R M, Api A M. Toxicol. Lett., 1999, 111: 169-174
[104] Api A M, San R H C. Mutat. Res. Gen. Tox. En. Mutagenesis, 1999, 446: 67-81
[105] Bitsch N, Dudas C, Korner W, Failing K, Biselli S, Rimkus G, Brunn H. Arch. Environ. Contam. Toxicol., 2002, 43: 257-264
[106] Van der Burg B, Schreurs R, van der Linden S, Seinen W, Brouwer A, Sonneveld E. Int. J. Androl., 2008, 31: 188-193
[107] Seinen W, Lemmen J C, Pieters R H H, Verbruggen E M J, van der Burg B. Toxicol. Lett., 1999, 111: 161-168
[108] Schreurs R H M M, Quaedackers M E, Seinen W, van der Burg B. Toxicol. Appl. Pharmacol., 2002, 183: 1-9
[109] Schreurs R H M M, Legler J, Artola-Garicano E, Sinnige T L, Lanser P H, Seinen W, van der Burg B. Environ. Sci. Technol., 2004, 38: 997-1002
[110] Schreurs R H M M, Sonneveld E, Jansen J H J, Seinen W, van der Burg B. Toxicol. Sci., 2005, 83: 264-272
[1] 周丽, Abdelkrim Yasmine, 姜志国, 于中振, 曲晋. 微塑料:生物效应、分析和降解方法综述[J]. 化学进展, 2022, 34(9): 1935-1946.
[2] 赵超, 蔡宗苇. 基于质谱成像和组学分析的环境毒理研究[J]. 化学进展, 2021, 33(4): 503-511.
[3] 宋志花, 李盛红, 杨刚强, 周娜, 陈令新. 人参皂苷类化合物样品前处理及分析检测[J]. 化学进展, 2020, 32(2/3): 239-248.
[4] 朱本占, 沈忱, 盛治国. 膜受体介导双酚A低剂量内分泌干扰效应的分子机制[J]. 化学进展, 2019, 31(1): 167-179.
[5] 王亚韡, 王莹, 江桂斌. 短链氯化石蜡的分析方法、污染现状与毒性效应[J]. 化学进展, 2017, 29(9): 919-929.
[6] 李忠民, 郭良宏. 氟调醇的环境污染与毒理学研究[J]. 化学进展, 2016, 28(7): 993-1005.
[7] 向垒, 孙腾飞, 莫测辉, 李彦文, 蔡全英, 李慧. 季铵盐类化合物环境问题研究进展[J]. 化学进展, 2016, 28(5): 727-736.
[8] 杨引, 樊梦醒, 郭智慧, 张卉, 吴萍, 蔡称心. DNA甲基化电化学分析[J]. 化学进展, 2014, 26(12): 1977-1986.
[9] 刘国瑞, 李丽, 孙素芳, 姜晓旭, 王美, 郑明辉. 多溴联苯的污染来源、分析方法和环境污染特征[J]. 化学进展, 2014, 26(08): 1434-1444.
[10] 史亚利, 蔡亚岐. 全氟和多氟化合物环境问题研究[J]. 化学进展, 2014, 26(04): 665-681.
[11] 支田田, 程丽华, 徐新华, 张林, 陈欢林. 藻类去除水体中重金属的机理及应用[J]. 化学进展, 2011, 23(8): 1782-1794.
[12] 王晓伟 刘景富 阴永光. 有机磷酸酯阻燃剂污染现状与研究进展*[J]. 化学进展, 2010, 22(10): 1983-1992.
[13] 马玲玲 徐殿斗 陈扬 柴之芳. 短链氯化石蜡分析方法*[J]. 化学进展, 2010, 22(04): 720-726.
[14] 刘永春,贺泓. 大气颗粒物化学组成分析*[J]. 化学进展, 2007, 19(10): 1620-1631.
[15] 蔡亚岐,史亚利,张萍,牟世芬,江桂斌. 高氯酸盐的环境污染问题*[J]. 化学进展, 2006, 18(11): 1554-1564.