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化学进展 2010, Vol. 22 Issue (07): 1380-1396 前一篇   后一篇

• 特约稿 •

不对称多组分反应

朱映光    翟昌伟    胡文浩*   

  1. (华东师范大学化学系    上海  200062)

     

  • 收稿日期:2009-12-17 出版日期:2010-07-24 发布日期:2010-07-02
  • 通讯作者: 胡文浩 E-mail:whu@chem.ecnu.edu.cn

Asymmetric Multicomponent Reactions

 Zhu  Yingguang    Di  Changwei    Hu  Wenhao*   

  1. (Department of Chemistry, East China Normal University, Shanghai 200062, China)
  • Received:2009-12-17 Online:2010-07-24 Published:2010-07-02
  • Contact: Hu Wenhao E-mail:whu@chem.ecnu.edu.cn

由于多组分反应自身所具有的优势及其在新药发现中的应用,多组分反应特别是不对称多组分反应成为一个非常有吸引力的研究领域。本文从非对映选择性和对映选择性控制两个方面对不对称多组分反应的最新研究进展进行了综述。重点介绍了反应中所使用的催化剂体系及有关反应机理。最后提出了不对称多组分反应研究中存在的一些问题,并对其今后的发展方向进行了展望。

Multicomponent reactions (MCRs), especially asymmetric multicomponent reactions (AMCRs), have received considerable attention due to their great intrinsic advantages as well as their applications in drug discovery. Recent progress on asymmetric multicomponent reactions (AMCRs) including diastereoslective and enantioselective approaches to chiral molecules is reviewed. The application of asymmetric catalysis and corresponding reaction mechanism are the major focus. It elicits issues and perspectives of AMCRs in the end.

Contents 
1 Introduction 
2 Asymmetric multicomponent reactions based on nucleophilic addition to imines
2.1 Strecker reaction 
2.2 Mannich reaction 
2.3 Biginelli reaction 
2.4 Petasis reaction 
2.5 Other imine additions 
3 Asymmetric Hantzsch reaction
4 Asymmetric multicomponent reactions via isocyanides 
4.1 Passerini reaction 
4.2 Ugi reaction 
5 Asymmetric multicomponent reactions based on cycloaddition 
5.1 Diels-Alder type reactions 
5.2 Tietze reactions 
5.3 1,3-dipolar cycloaddition type reactions
6 Asymmetric multicomponent reactions based on Michael-addition 
6.1 Michael-Aldol type reactions 
6.2 Knoevenagel-Michael type reactions 
6.3 Double Michael reactions 
6.4 Carbometalation-Michael multicomponent reactions 
7 Asymmetric multicomponent reactions based on trapping of alcoholic oxonium ylide 
8 Conclusions and perspectives

中图分类号: 

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