• 综述与评论 •
古孝雪, 于晶, 杨明英, 帅亚俊. 丝素蛋白3D打印在生物医学领域中的应用[J]. 化学进展, 2022, 34(6): 1359-1368.
Xiaoxue Gu, Jing Yu, Mingying Yang, Yajun Shuai. Silk Fibroin-Based 3D Printing Strategies for Biomedical Applications[J]. Progress in Chemistry, 2022, 34(6): 1359-1368.
增材制造,也称为三维(3D)打印,正推动制造、工程、医学等领域的全面创新升级。3D打印技术由于能够个性化定制生物的复杂3D微结构,构建仿生的功能化活组织或人工器官,近十年来在生物医学领域中取得了长足的发展。丝素蛋白(SF)是一种来源丰富、生物可降解、力学性能优良、细胞相容性极佳的天然有机高分子,为3D打印墨水的设计提供了一种有前景的选择。然而,作为结构蛋白,单一组分的SF具有的生理功能有限,且其经过打印后的稳定性较差,限制了SF在3D打印以及生物医药领域中的进一步发展。为此,研究人员通过化学改性技术和先进3D打印技术相结合,使得改性后的SF能够更适用于3D打印,并发展成为一种具有应用价值的生物材料。本文综述了SF的结构特征、SF的化学修饰策略、打印墨水的制备策略以及3D打印SF材料在生物医学领域的最新应用进展,并展望了3D打印SF生物材料的未来发展趋势,为其在更广阔领域的应用提供一定的借鉴。
分享此文:
Types of bio-inks | Printing methods | Young’s modulus | Print resolution (μm) | Tissues or cells | ref |
---|---|---|---|---|---|
SF-Gelatin (Composite) | Extrusion | 1.4 kPa | 65~200 | Soft tissue | |
SF-GelMA (Composite) | Extrusion | 40 kPa | 300 | Endothelial cells | |
SF- HA (Composite) | Inkjet | NA | 80 | Hard tissue | |
SF-cellulose nanofibers (Composite) | Extrusion | 267 kPa | 410 | Lung cells | |
SF-cellulose nanofibers (Composite) | Extrusion | 187 kPa | 400 | Meniscus | |
SF (Self cross-linking) | Inkjet | NA | 200 | Fibroblast cells | |
SF (Self cross-linking ) | Extrusion | 5.6 GPa | 100 | Cartilage tissue | |
SF-Methacrylic (Modification) | Photo-curing | 15 kPa | 70 | Cartilage tissue |
[1] |
Vepari C, Kaplan D L. Prog. Polym. Sci., 2007, 32(8/9): 991.
doi: 10.1016/j.progpolymsci.2007.05.013 URL |
[2] |
Wan Q, Yang M, Hu J Q, Lei F, Shuai Y J, Wang J, Holland C, Rodenburg C, Yang M Y. Nat. Commun., 2021, 12: 3711.
doi: 10.1038/s41467-021-23960-w URL |
[3] |
Shuai Y J, Yang S X, Li C L, Zhu L J, Mao C B, Yang M Y. J. Mater. Chem. B, 2017, 5(21): 3945.
doi: 10.1039/C7TB00208D URL |
[4] |
Yang M Y, Shuai Y J, Zhou G S, Mandal N, Zhu L J. Bio Med. Mater. Eng., 2014, 24(1): 731.
|
[5] |
Yodmuang S, McNamara S L, Nover A B, Mandal B B, Agarwal M, Kelly T A N, Chao P H G, Hung C, Kaplan D L, Vunjak-Novakovic G. Acta Biomater., 2015, 11: 27.
doi: 10.1016/j.actbio.2014.09.032 pmid: 25281788 |
[6] |
Gu M J, Zhao F X, Fan S N, Ma K, Yao X, Zhang Y P. J. Funct. Mater., 2021, 52(6): 6110.
|
( 谷敏婧, 赵飞翔, 范苏娜, 马凯, 姚响, 张耀鹏. 功能材料, 2021, 52(6): 6110.)
|
|
[7] |
Liao J G, Li Y Q, Duan X Z, Zhu L L. Progress in Chemistry, 2015, 27(Z1): 220.
|
( 廖建国, 李艳群, 段星泽, 朱伶俐. 化学进展, 2015, 27(Z1): 220.)
|
|
[8] |
Shuai Y J, Lu H, Lv R Y, Wang J, Wan Q, Mao C B, Yang M Y. Adv. Healthcare Mater., 2021, 10(8): 2001695.
doi: 10.1002/adhm.202001695 URL |
[9] |
Shuai Y J, Wang J, Zhang Q, Fang J J, Zhu L J, Yang M Y. Science of Sericulture, 2017, 43(6): 889.
|
( 帅亚俊, 王捷, 张青, 方建军, 朱良均, 杨明英. 蚕业科学, 2017, 43(6): 889.)
|
|
[10] |
Dong D D, Zhang J W, Wang J, Yang K, Ma Z L, Zhang W B, Chen Y M, Ma J Z. Acta Polymerica Sinica, 2020, 51(08): 864.
|
( 董点点, 张静雯, 王军, 杨宽, 马忠雷, 张文博, 陈咏梅, 马建中. 高分子学报, 2020, 51(08): 864.)
|
|
[11] |
Wang M M, Han Q Q. Chinese Journal of Medical Instrumentation, 2021, 45(03): 301.
|
( 王苗苗, 韩倩倩. 中国医疗器械杂志, 2021, 45(03): 301.)
|
|
[12] |
Li S T, Shi X W, Xu B, Zhen P, Li S K. Chinese Journal of Reparative and Reconstructive Surgery, 2021, 35(9): 1.
|
( 李胜堂, 石学文, 徐博, 甄平, 李松凯. 中国修复重建外科杂志, 2021, 35(9): 1.)
|
|
[13] |
Gupta S, Bissoyi A, Bit A. BioNanoScience, 2018, 8(3): 868.
doi: 10.1007/s12668-018-0525-4 URL |
[14] |
Wu C S, Wang B, Zhang C, Wysk R A, Chen Y W. Crit. Rev. Biotechnol., 2017, 37(3): 333.
doi: 10.3109/07388551.2016.1163321 URL |
[15] |
Mandrycky C, Wang Z J, Kim K, Kim D H. Biotechnol. Adv., 2016, 34(4): 422.
doi: 10.1016/j.biotechadv.2015.12.011 URL |
[16] |
Chia H N, Wu B M. J. Biol. Eng., 2015, 9: 4.
doi: 10.1186/s13036-015-0001-4 URL |
[17] |
Mu X, Fitzpatrick V, Kaplan D L. Adv. Healthcare Mater., 2020, 9(15): 1901552.
doi: 10.1002/adhm.201901552 URL |
[18] |
Agostinacchio F, Mu X, Dirè S, Motta A, Kaplan D L. Trends Biotechnol., 2021, 39(7): 719.
doi: 10.1016/j.tibtech.2020.11.003 URL |
[19] |
Jin Z, Li Y R, Yu K, Liu L X, Fu J Z, Yao X H, Zhang A G, He Y. Adv. Sci., 2021, 8(17): 2101394.
doi: 10.1002/advs.202101394 URL |
[20] |
Rodriguez M J, Brown J, Giordano J, Lin S J, Omenetto F G, Kaplan D L. Biomaterials, 2017, 117: 105.
doi: S0142-9612(16)30673-1 pmid: 27940389 |
[21] |
Shi W L, Sun M Y, Hu X Q, Ren B, Cheng J, Li C X, Duan X N, Fu X, Zhang J Y, Chen H F, Ao Y F. Adv. Mater., 2017, 29(29): 1701089.
doi: 10.1002/adma.201701089 URL |
[22] |
Singh Y P, Bandyopadhyay A, Mandal B B. ACS Appl. Mater. Interfaces, 2019, 11(37): 33684.
doi: 10.1021/acsami.9b11644 URL |
[23] |
Vyas C, Zhang J, Øvrebø Ø, Huang B Y, Roberts I, Setty M, Allardyce B, Haugen H, Rajkhowa R, Bartolo P. Mater. Sci. Eng. C, 2021, 118: 111433.
doi: 10.1016/j.msec.2020.111433 URL |
[24] |
Konwarh R. Curr. Sci. India, 2020, 118 (3): 345.
|
[25] |
Rockwood D N, Preda R C, Yücel T, Wang X Q, Lovett M L, Kaplan D L. Nat. Protoc., 2011, 6(10): 1612.
doi: 10.1038/nprot.2011.379 URL |
[26] |
Shuai Y J, Mao C B, Yang M Y. ACS Appl. Mater. Interfaces, 2018, 10(38): 31988.
doi: 10.1021/acsami.8b11811 URL |
[27] |
Hakimi O, Knight D P, Vollrath F, Vadgama P. Compos. B Eng., 2007, 38(3): 324.
doi: 10.1016/j.compositesb.2006.06.012 URL |
[28] |
Laity P R, Gilks S E, Holland C. Polymer, 2015, 67: 28.
doi: 10.1016/j.polymer.2015.04.049 URL |
[29] |
Bhattacharjee M, Chawla S, Chameettachal S, Murab S, Bhavesh N S, Ghosh S. Biomed. Mater., 2016, 11(2): 025014.
doi: 10.1088/1748-6041/11/2/025014 URL |
[30] |
Karageorgiou V, Meinel L, Hofmann S, Malhotra A, Volloch V, Kaplan D. J. Biomed. Mater. Res., 2004, 71A(3): 528.
doi: 10.1002/jbm.a.30186 URL |
[31] |
Murab S, Chameettachal S, Bhattacharjee M, Das S, Kaplan D L, Ghosh S. Tissue Eng. A, 2013, 19(15/16): 1733.
doi: 10.1089/ten.tea.2012.0385 URL |
[32] |
Hölzl K, Lin S M, Tytgat L, van Vlierberghe S, Gu L X, Ovsianikov A. Biofabrication, 2016, 8(3): 032002.
doi: 10.1088/1758-5090/8/3/032002 URL |
[33] |
Tao H, Marelli B, Yang M M, An B, Onses M S, Rogers J A, Kaplan D L, Omenetto F G. Adv. Mater., 2015, 27(29): 4273.
doi: 10.1002/adma.201501425 URL |
[34] |
Mehrotra S, Melo B A G, Hirano M, Keung W, Li R A, Mandal B B, Shin S R. Adv. Funct. Mater., 2020, 30(12): 2070079.
doi: 10.1002/adfm.202070079 URL |
[35] |
Rider P, Brook I, Smith P, Miller C. Micromachines, 2018, 9(2): 46.
doi: 10.3390/mi9020046 URL |
[36] |
Huang L, Yuan W, Hong Y, Fan S N, Yao X, Ren T, Song L J, Yang G S, Zhang Y P. Cellulose, 2021, 28(1): 241.
doi: 10.1007/s10570-020-03526-7 URL |
[37] |
Huang L, Du X Y, Fan S N, Yang G H, Shao H L, Li D J, Cao C B, Zhu Y F, Zhu M F, Zhang Y P. Carbohyd. Polym., 2019, 221: 146.
doi: S0144-8617(19)30595-8 pmid: 31227153 |
[38] |
Rider P, Zhang Y, Tse C, Zhang Y, Jayawardane D, Stringer J, Callaghan J, Brook I M, Miller C A, Zhao X B, Smith P J. J. Mater. Sci., 2016, 51(18): 8625.
doi: 10.1007/s10853-016-0121-3 URL |
[39] |
Ghosh S, Parker S T, Wang X Y, Kaplan D L, Lewis J A. Adv. Funct. Mater., 2008, 18(13): 1883.
doi: 10.1002/adfm.200800040 URL |
[40] |
Kim S H, Yeon Y K, Lee J M, Chao J R, Lee Y, Seo Y B, Lee O J, Yoon S. Nat. Commun., 2018, S 9 (1): 1.
doi: 10.1038/s41467-017-02088-w URL |
[41] |
Dong T, Mi R X, Wu M, Zhong N P, Zhao X, Chen X, Shao Z Z. J. Mater. Chem. B, 2019, 7(27): 4328.
doi: 10.1039/c9tb00783k |
[42] |
Kim E, Seok J M, Bae S B, Park S A, Park W H. Biomacromolecules, 2021, 22(5): 1921.
doi: 10.1021/acs.biomac.1c00034 URL |
[43] |
Compaan A M, Christensen K, Huang Y. ACS Biomater. Sci. Eng., 2017, 3(8): 1519.
doi: 10.1021/acsbiomaterials.6b00432 URL |
[44] |
Mannoor M S, Jiang Z W, James T, Kong Y L, Malatesta K A, Soboyejo W O, Verma N, Gracias D H, McAlpine M C. Nano Lett., 2013, 13(6): 2634.
doi: 10.1021/nl4007744 pmid: 23635097 |
[45] |
Chimene D, Lennox K K, Kaunas R R, Gaharwar A K. Ann. Biomed. Eng., 2016, 44(6): 2090.
doi: 10.1007/s10439-016-1638-y pmid: 27184494 |
[46] |
Jungst T, Smolan W, Schacht K, Scheibel T, Groll J. Chem. Rev., 2016, 116(3): 1496.
doi: 10.1021/acs.chemrev.5b00303 URL |
[47] |
Sakai S, Yoshii A, Sakurai S, Horii K, Nagasuna O. Mater. Today Bio., 2020, 8: 100078.
|
[48] |
Pudkon W, Laomeephol C, Damrongsakkul S, Kanokpanont S, Ratanavaraporn J. Molecules, 2021, 26(13): 3887.
doi: 10.3390/molecules26133887 URL |
[49] |
Zhang J, Allardyce B J, Rajkhowa R, Kalita S, Dilley R J, Wang X G, Liu X. Mater. Sci. Eng. C, 2019, 103: 109784.
doi: 10.1016/j.msec.2019.109784 URL |
[50] |
Zheng Z Z, Wu J B, Liu M, Wang H, Li C M, Rodriguez M J, Li G, Wang X Q, Kaplan D L. Adv. Healthcare Mater., 2018, 7(6): 1701026.
doi: 10.1002/adhm.201701026 URL |
[51] |
Du X Y, Wei D X, Huang L, Zhu M, Zhang Y P, Zhu Y F. Mater. Sci. Eng. C, 2019, 103: 109731.
doi: 10.1016/j.msec.2019.05.016 URL |
[52] |
Ajiteru O, Sultan M T, Lee Y J, Seo Y B, Hong H, Lee J S, Lee H N, Suh Y J, Ju H W, Lee O J, Park H S, Jang M, Kim S H, Park C H. Nano Lett., 2020, 20(9): 6873.
doi: 10.1021/acs.nanolett.0c02986 URL |
[53] |
Gong D F, Lin Q R, Shao Z Z, Chen X, Yang Y H. RSC Adv., 2020, 10(45): 27225.
doi: 10.1039/D0RA04789A URL |
[54] |
Freddi G, Anghileri A, Sampaio S, Buchert J, Monti P, Taddei P. J. Biotechnol., 2006, 125(2): 281.
doi: 10.1016/j.jbiotec.2006.03.003 URL |
[55] |
Murphy A R, John P S, Kaplan D L. Biomaterials, 2008, 29(19): 2829.
doi: 10.1016/j.biomaterials.2008.03.039 URL |
[56] |
Costa J B, Silva-Correia J, Oliveira J M, Reis R L. Adv. Healthcare Mater., 2017, 6(22): 1701021.
doi: 10.1002/adhm.201701021 URL |
[57] |
Hong H, Seo Y B, Kim D Y, Lee J S, Lee Y J, Lee H N, Ajiteru O, Sultan M T, Lee O J, Kim S H, Park C H. Biomaterials, 2020, 232: 119679.
doi: 10.1016/j.biomaterials.2019.119679 URL |
[58] |
Shin D, Hyun J. J. Ind. Eng. Chem., 2021, 95: 126.
doi: 10.1016/j.jiec.2020.12.011 URL |
[59] |
Whittaker J L, Choudhury N R, Dutta N K, Zannettino A. J. Mater. Chem. B, 2014, 2(37): 6259.
doi: 10.1039/c4tb00698d pmid: 32262143 |
[60] |
Cui X L, Solim an B G, Alcala-Orozco C R, Li J, Vis M A M, Santos M, Wise S G, Levato R, Malda J, Woodfield T B F, Rnjak-Kovacina J, Lim K S. Adv. Healthcare Mater., 2020, 9(22): 2001801.
doi: 10.1002/adhm.202001801 URL |
[61] |
Zhong N P, Dong T, Chen Z C, Guo Y W, Shao Z Z, Zhao X. J. Biomater. Appl., 2019, 34(1): 3.
doi: 10.1177/0885328219845092 URL |
[62] |
Li X D, Liu B X, Pei B, Chen J W, Zhou D Z, Peng J Y, Zhang X Z, Jia W, Xu T. Chem. Rev., 2020, 120(19): 10793.
doi: 10.1021/acs.chemrev.0c00008 URL |
[63] |
Zhao Y H, Niu C M, Shi J Q, Wang Y Y, Yang Y M, Wang H B. Neural Regen. Res., 2018, 13 (8): 1455.
doi: 10.4103/1673-5374.235303 pmid: 30106059 |
[64] |
Mu Q Y, Wang L, Dunn C K, Kuang X, Duan F, Zhang Z, Qi H J, Wang T J. Addit. Manuf., 2017, 18: 74.
|
[65] |
de Gans B J, Duineveld P C, Schubert U S. Adv. Mater., 2004, 16(3): 203.
doi: 10.1002/adma.200300385 URL |
[66] |
Singh M, Haverinen H M, Dhagat P, Jabbour G E. Adv. Mater., 2010, 22(6): 673.
doi: 10.1002/adma.200901141 URL |
[67] |
Calvert P. Chem. Mater., 2001, 13(10): 3299.
doi: 10.1021/cm0101632 URL |
[68] |
Limem S, Calvert P, Kim H J, Kaplan D L. J. Imaging Sci. Technol., 2006, 2006 (3): 99.
|
[69] |
Ozbolat I T, Hospodiuk M. Biomaterials, 2016, 76: 321.
doi: 10.1016/j.biomaterials.2015.10.076 URL |
[70] |
Placone J K, Engler A J. Adv. Healthcare Mater., 2018, 7(8): 1701161.
doi: 10.1002/adhm.201701161 URL |
[71] |
Chawla S, Midha S, Sharma A, Ghosh S. Adv. Healthcare Mater., 2018, 7(8): 1701204.
doi: 10.1002/adhm.201701204 URL |
[72] |
Das S, Pati F, Chameettachal S, Pahwa S, Ray A R, Dhara S, Ghosh S. Biomacromolecules, 2013, 14(2): 311.
doi: 10.1021/bm301193t URL |
[73] |
Chameettachal S, Midha S, Ghosh S. ACS Biomater. Sci. Eng., 2016, 2(9): 1450.
doi: 10.1021/acsbiomaterials.6b00152 URL |
[74] |
Nemir S, West J L. Ann. Biomed. Eng., 2010, 38(1): 2.
doi: 10.1007/s10439-009-9811-1 URL |
[75] |
Woodfield T B F, Malda J, de Wijn J, Péters F, Riesle J, van Blitterswijk C A, Biomaterials, 2004, 25(18): 4149.
pmid: 15046905 |
[76] |
Mirfakhrai T, Madden J D W, Baughman R H. Mater. Today, 2007, 10(4): 30.
|
[77] |
Jose R R, Brown J E, Polido K E, Omenetto F G, Kaplan D L. ACS Biomater. Sci. Eng., 2015, 1(9): 780.
doi: 10.1021/acsbiomaterials.5b00160 URL |
[78] |
Zhu W, Ma X Y, Gou M L, Mei D Q, Zhang K, Chen S C. Curr. Opin. Biotechnol., 2016, 40: 103.
doi: 10.1016/j.copbio.2016.03.014 URL |
[79] |
Grogan S P, Chung P H, Soman P, Chen P, Lotz M K, Chen S C, D’Lima D D. Acta Biomater., 2013, 9(7): 7218.
doi: 10.1016/j.actbio.2013.03.020 pmid: 23523536 |
[80] |
Zheng X Y, Smith W, Jackson J, Moran B, Cui H C, Chen D, Ye J C, Fang N, Rodriguez N, Weisgraber T, Spadaccini C M. Nat. Mater., 2016, 15(10): 1100.
doi: 10.1038/nmat4694 URL |
[81] |
Zeng Y, Yan Y Z, Yan H F, Liu C C, Li P R, Dong P, Zhao Y, Chen J M. J. Mater. Sci., 2018, 53(9): 6291.
doi: 10.1007/s10853-018-1992-2 URL |
[82] |
Na K, Shin S, Lee H, Shin D, Baek J, Kwak H, Park M, Shin J, Hyun J. J. Ind. Eng. Chem., 2018, 61: 340.
doi: 10.1016/j.jiec.2017.12.032 URL |
[83] |
Melchels F P W, Feijen J, Grijpma D W. Biomaterials, 2010, 31(24): 6121.
doi: 10.1016/j.biomaterials.2010.04.050 pmid: 20478613 |
[84] |
Lin H, Zhang D N, Alexander P G, Yang G, Tan J, Cheng A W M, Tuan R S. Biomaterials, 2013, 34(2): 331.
doi: 10.1016/j.biomaterials.2012.09.048 URL |
[85] |
Zhang A P, Qu X, Soman P, Hribar K C, Lee J W, Chen S C, He S L. Adv. Mater., 2012, 24(31): 4266.
doi: 10.1002/adma.201202024 URL |
[86] |
Shin S, Kwak H, Hyun J. ACS Appl. Mater. Interfaces, 2018, 10(28): 23573.
doi: 10.1021/acsami.8b05963 URL |
[87] |
Jeyaraj R, G N, Kirby G, Rajadas J, Mosahebi A, Seifalian A M, Tan A. Mater. Sci. Eng. C, 2015, 54: 225.
doi: 10.1016/j.msec.2015.05.045 URL |
[88] |
Stocco E, Barbon S, Dalzoppo D, Lora S, Sartore L, Folin M, Parnigotto P P, Grandi C. Biomed Res. Int., 2014, 2014: 762189.
|
[89] |
Do A V, Khorsand B, Geary S M, Salem A K. Adv. Healthcare Mater., 2015, 4(12): 1742.
doi: 10.1002/adhm.201500168 URL |
[90] |
Xiao W Q, Li J L, Qu X H, Wang L L, Tan Y F, Li K J, Li H, Yue X Z, Li B, Liao X L. Mat. Sci. Eng. C-Mater., 2019, 99: 57.
doi: 10.1016/j.msec.2019.01.079 URL |
[91] |
Zhao R, Yang X, Zhu X D, Zhang X D. Progress in Chemistry, 2021, 33 (04): 533.
|
( 赵睿, 杨晓, 朱向东, 张兴栋. 化学进展, 2021, 33 (04) : 533.)
|
|
[92] |
Sun L, Parker S T, Syoji D, Wang X L, Lewis J A, Kaplan D L. Adv. Healthc. Mater., 2012, 1(6): 729.
doi: 10.1002/adhm.201200057 URL |
[93] |
Bouwstra J A, Honeywell-Nguyen P L. Adv. Drug Deliv. Rev., 2002, 54: S41.
doi: 10.1016/S0169-409X(02)00114-X URL |
[94] |
Lin J Y, Luo S H, Yang C L, Xiao Y, Yang L T, Wang C Y. Progress in Chemistry, 2021, 33 (04): 581.
|
( 林建云, 罗时荷, 杨崇岭, 肖颖, 杨丽庭, 汪朝阳. 化学进展, 2021, 33 (04): 581.)
|
|
[95] |
Chawla S, Ghosh S. Acta Biomater., 2018, 69: 131.
doi: 10.1016/j.actbio.2018.01.002 URL |
[96] |
Xiong S, Zhang X Z, Lu P, Wu Y, Wang Q, Sun H, Heng B C, Bunpetch V, Zhang S F, Ouyang H. Sci. Rep., 2017, 7: 4288.
doi: 10.1038/s41598-017-04149-y pmid: 28655891 |
[97] |
Kim S H, Seo Y B, Yeon Y K, Song S H, Lee K H, Park C H. Biomaterials, 2020, 260: 120281.
doi: 10.1016/j.biomaterials.2020.120281 URL |
[1] | 赵睿, 杨晓, 朱向东, 张兴栋. 微量元素锶掺杂生物材料在骨修复领域的应用[J]. 化学进展, 2021, 33(4): 533-542. |
[2] | 贺丽娟, 孔德隆, 徐彩虹, 雷朝帅, 李文静, 赵英民. 聚合物前驱体3D打印制备高性能陶瓷[J]. 化学进展, 2020, 32(12): 1978-1989. |
[3] | 刘杰, 曾渊, 张俊, 张海军, 刘江昊. 三维石墨烯基材料的制备、结构与性能[J]. 化学进展, 2019, 31(5): 667-680. |
[4] | 左新钢, 张昊岚, 周同, 高长有. 调控细胞迁移和组织再生的生物材料研究[J]. 化学进展, 2019, 31(11): 1576-1590. |
[5] | 韩毅, 董海青, 李胜, 李维达, 李永勇. 胰岛封装技术及其在胰岛移植中的应用[J]. 化学进展, 2018, 30(11): 1660-1668. |
[6] | 蒋敏, 王敏, 魏仕勇, 陈志宝, 木士春. 基于静电纺丝技术的取向纳米纤维[J]. 化学进展, 2016, 28(5): 711-726. |
[7] | 刘宗光, 屈树新, 翁杰. 聚多巴胺在生物材料表面改性中的应用[J]. 化学进展, 2015, 27(2/3): 212-219. |
[8] | 程新峰, 金勇, 漆锐, 樊宝珠, 李汉平. 刺激响应降解型聚合物水凝胶[J]. 化学进展, 2015, 27(12): 1784-1798. |
[9] | 刘小波, 寇宗魁, 木士春. 多孔石墨烯材料[J]. 化学进展, 2015, 27(11): 1566-1577. |
[10] | 许利娜, 马培培, 陈强, 林思聪, 沈健. 甲基丙烯酰乙基磺基甜菜碱类聚合物的生物应用[J]. 化学进展, 2014, 26(0203): 366-374. |
[11] | 李春鸽, 赵爽, 李俊杰, 尹玉姬*. 含巯基/二硫键聚合物生物材料[J]. 化学进展, 2013, 25(01): 122-134. |
[12] | 马梦佳, 陈玉云, 闫志强, 丁剑, 何丹农*, 钟建*. 原子力显微镜在纳米生物材料研究中的应用[J]. 化学进展, 2013, 25(01): 135-144. |
[13] | 唐诗洋, 孙晓君, 林丽, 孙艳, 刘献斌. 单分散介孔氧化硅纳米颗粒的制备及其在生物材料方面的应用[J]. 化学进展, 2011, 23(9): 1973-1984. |
[14] | 王玮, 李博, 高长有. 生物材料表面性能调控骨髓间充质干细胞分化[J]. 化学进展, 2011, 23(10): 2160-2168. |
[15] | 邱媛 章继川 高长有. 用于肝细胞球形聚集体培养的生物材料*[J]. 化学进展, 2010, 22(09): 1826-1835. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||